EP 1345893 A2 20030924 - SULPHUR-CONTAINING AMPHIPHILIC AGENTS FOR THE TRANSFER OF BIOLOGICALLY ACTIVE MOLECULES INTO CELLS
Title (en)
SULPHUR-CONTAINING AMPHIPHILIC AGENTS FOR THE TRANSFER OF BIOLOGICALLY ACTIVE MOLECULES INTO CELLS
Title (de)
SCHWEFELHALTIGE AMPHIPHILE FÜR DEN TRANSFER VON BIOLOGISCH AKTIVEN MOLEK LEN IN ZELLEN
Title (fr)
AMPHIPHILES SULFUREUX POUR LE TRANSFERT DE MOLECULES BIOACTIVES DANS DES CELLULES
Publication
Application
Priority
- DE 0104843 W 20011221
- DE 10064870 A 20001227
Abstract (en)
[origin: WO02051800A2] The invention relates to amphiphilic, cationic, sulpho-substituted phosphatidylethanolamine analogues and salts thereof, which can complex biopolymers such as DNA, RNA, oligonucleotides, ribozymes, proteins and peptides and introduce the above into eukaryotic cells. Particularly suitable are compounds derived from 1,2-dioleoyl-3-sn-phosphatidylethanolamine (DOPE) and in which the phosphate ester group of DOPE is replaced by an isosteric group CH2-SO-CH2 or CH2S(O)2-CH2. Said compounds are particularly suitable for application in gene therapy and also for diagnostic purposes as a result of the property thereof of forming aggregates with biologically active molecules such as DNA or RNA for example.
IPC 1-7
IPC 8 full level
A61K 9/127 (2006.01); A61K 47/48 (2006.01); C07C 317/28 (2006.01); C12N 15/88 (2006.01)
CPC (source: EP US)
A61K 9/1272 (2013.01 - EP US); A61K 47/6911 (2017.07 - EP US); C07C 317/28 (2013.01 - EP US); C12N 15/88 (2013.01 - EP US)
Citation (search report)
See references of WO 02051800A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 02051800 A2 20020704; WO 02051800 A3 20020815; DE 10064870 A1 20020711; DE 10064870 B4 20041007; EP 1345893 A2 20030924; US 2005048108 A1 20050303
DOCDB simple family (application)
DE 0104843 W 20011221; DE 10064870 A 20001227; EP 01990354 A 20011221; US 45168704 A 20040130