EP 1345966 A2 20030924 - CRYSTALLIZED CYTOPLASMIC TIE2 RECEPTOR TYROSINE KINASE DOMAIN AND METHOD OF DETERMINING AND DESIGNING MODULATORS OF THE SAME
Title (en)
CRYSTALLIZED CYTOPLASMIC TIE2 RECEPTOR TYROSINE KINASE DOMAIN AND METHOD OF DETERMINING AND DESIGNING MODULATORS OF THE SAME
Title (de)
KRISTALLISIERTE ZYTOPLASMATISCHE TIE2 REZEPTOR-TYROSINKINASE DOMÄNE UND VERFAHREN ZUR FESTSTELLUNG UND ZUM DESIGN IHRER MODULATOREN
Title (fr)
DOMAINE CYTOPLASMIQUE CRISTALLISE DE RECEPTEUR TYROSINE KINASE TIE2, ET PROCEDE PERMETTANT DE DETERMINER ET DE CONCEVOIR DES MODULATEURS DE CE DERNIER
Publication
Application
Priority
- US 0127486 W 20010906
- US 23139800 P 20000908
Abstract (en)
[origin: WO0220734A2] A solved three-dimensional crystal structure of a cytoplasmic Tie2 receptor tyrosine kinase domain is disclosed, along with four crystal forms of the cytoplasmic Tie2 receptor tyrosine kinase domain. The crystal forms include non- and monophosphorylated forms of the cytoplasmic Tie2 receptor tyrosine kinase domain. Methods of designing modulators of the biological activity of the cytoplasmic Tie2 receptor tyrosine kinase domain are also disclosed.
IPC 1-7
IPC 8 full level
C07K 14/71 (2006.01)
CPC (source: EP)
C07K 14/71 (2013.01)
Citation (search report)
See references of WO 0220734A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0220734 A2 20020314; WO 0220734 A3 20030619; AU 8873501 A 20020322; EP 1345966 A2 20030924
DOCDB simple family (application)
US 0127486 W 20010906; AU 8873501 A 20010906; EP 01968491 A 20010906