Global Patent Index - EP 1351691 A1

EP 1351691 A1 20031015 - SUBSTITUTED 2-ARYL-4-ARYLAMINOPYRIMIDINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF

Title (en)

SUBSTITUTED 2-ARYL-4-ARYLAMINOPYRIMIDINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF

Title (de)

SUBSTITUIERTE 2-ARYL-4-ARYLAMINOPYRIMIDINE UND IHRE ANALOGE ALS AKTIVATOREN VON CASPASEN UND APOPTOSEINDUKTOREN, SOWIE DEREN VERWENDUNG

Title (fr)

2-ARYL-4-ARYLAMINOPYRIMIDINES SUBSTITUEES ET ANALOGUES EN TANT QU'ACTIVATEURS DE CASPASES ET QU'INDUCTEURS D'APOPTOSE, ET UTILISATION ASSOCIEE

Publication

EP 1351691 A1 20031015 (EN)

Application

EP 01990048 A 20011212

Priority

  • US 0147498 W 20011212
  • US 25458100 P 20001212

Abstract (en)

[origin: WO0247690A1] The present invention is directed to substituted 2-aryl-4-arylamino-pyrimidine and analogs thereof, represented by the general Formula I: wherein A, Ar1, Ar2, and R1 and R3 are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. The compounds of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

IPC 1-7

A61K 31/50; A61K 31/53; A61K 31/505

IPC 8 full level

A61K 31/50 (2006.01); A61K 31/505 (2006.01); A61K 31/506 (2006.01); A61K 31/53 (2006.01); A61P 35/00 (2006.01); C07D 239/42 (2006.01); C07D 239/48 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 405/14 (2006.01); C07D 417/04 (2006.01); C07D 417/14 (2006.01)

CPC (source: EP)

A61K 31/50 (2013.01); A61K 31/505 (2013.01); A61K 31/53 (2013.01); A61P 35/00 (2017.12); C07D 239/42 (2013.01); C07D 239/48 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 405/14 (2013.01); C07D 417/04 (2013.01); C07D 417/14 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

Designated extension state (EPC)

AL LT LV MK RO SI

DOCDB simple family (publication)

WO 0247690 A1 20020620; AU 2892202 A 20020624; EP 1351691 A1 20031015; EP 1351691 A4 20050622

DOCDB simple family (application)

US 0147498 W 20011212; AU 2892202 A 20011212; EP 01990048 A 20011212