EP 1351966 A1 20031015 - IMPROVED SPECIFICITY IN TREATMENT OF DISEASES
Title (en)
IMPROVED SPECIFICITY IN TREATMENT OF DISEASES
Title (de)
VERBESSERTE SPEZIFITÄT IN DER BEHANDLUNG VON KRANKHEITEN
Title (fr)
SPECIFICITE AMELIOREE DANS LE TRAITEMENT DE MALADIES
Publication
Application
Priority
- US 0033454 W 20001207
- US 22694800 P 20000822
- US 22687000 P 20000822
- US 22687100 P 20000822
Abstract (en)
[origin: WO0216382A1] A drug is modified by covalently coupling a blocking group to the drug via a nitrogen atom in the blocking group. The blocking group in the modified drug prevents metabolic conversion and sequestration of the drug in non-target cells, and the blocking group is enzymatically removed in the target cell. Particularly contemplated advantages of presented compounds and methods include reduction of cytotoxicity by inhibition of metabolic conversion to potentially cytotoxic metabolites, reduction of dosages of drugs by reduction of sequestration into non-target cells, and increase of selectivity of a drug.
IPC 1-7
IPC 8 full level
A61K 31/7056 (2006.01); A61K 31/7084 (2006.01); A61K 47/48 (2006.01); A61K 45/00 (2006.01); A61P 1/16 (2006.01); A61P 7/00 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07H 19/052 (2006.01); C07H 19/056 (2006.01)
CPC (source: EP KR)
A61K 31/7052 (2013.01 - KR); A61P 1/16 (2018.01 - EP); A61P 7/00 (2018.01 - EP); A61P 31/12 (2018.01 - EP); A61P 35/00 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07H 19/052 (2013.01 - EP); C07H 19/056 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0216382 A1 20020228; AU 2080601 A 20020304; BR 0017318 A 20040615; CA 2416748 A1 20020228; CN 1460109 A 20031203; CZ 2003460 A3 20031015; EP 1351966 A1 20031015; HU P0302882 A2 20031229; HU P0302882 A3 20050628; IL 154168 A0 20030731; JP 2004518618 A 20040624; KR 20030040415 A 20030522; MX PA03001528 A 20040402; NO 20030762 D0 20030218; NO 20030762 L 20030422; PL 365879 A1 20050110; TW 200414903 A 20040816
DOCDB simple family (application)
US 0033454 W 20001207; AU 2080601 A 20001207; BR 0017318 A 20001207; CA 2416748 A 20001207; CN 00819838 A 20001207; CZ 2003460 A 20001207; EP 00984134 A 20001207; HU P0302882 A 20001207; IL 15416800 A 20001207; JP 2002521479 A 20001207; KR 20037002538 A 20030221; MX PA03001528 A 20001207; NO 20030762 A 20030218; PL 36587900 A 20001207; TW 92102500 A 20030207