EP 1353919 B1 20060726 - NOVEL QUINUCLIDINE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME
Title (en)
NOVEL QUINUCLIDINE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME
Title (de)
NEUE CHINUCLIDINDERIVATE UND MEDIZINISCHE ZUSAMMENSETZUNGEN, DIE DIESE VERBINDUNGEN ENTHALTEN
Title (fr)
NOUVEAUX DERIVES DE QUINUCLIDINE ET COMPOSITIONS MEDICINALES CONTENANT CES DERNIERS
Publication
Application
Priority
- EP 0115168 W 20011220
- ES 200003130 A 20001228
Abstract (en)
[origin: WO02053564A2] A compound of formula (I), wherein B is a phenyl ring, a 5 to 10 membered heteroaromatic group containing one or more heteroatoms, or a naphthalenyl, 5, 6, 7, 8- tetrahydronaphthalenyl, benzo[1,3]dioxolyl, or biphenyl group; R1, R2 and R3 each independently represent a hydrogen or halogen atom, or a hydroxy group, a phenyl group, -OR<7>, -SR<7>, -NR<7>R<8>, -NHCOR<7>, -CONR<7>R<8>, -CN, -NO2, -COOR<7> or CF3 group, or a strait or branched, substituted or unsubstituted lower alkyl group, wherein R<7> and R<8> each independently represent a hydrogen atom, a straight or branched lower alkyl group, or together form an alicyclic ring; or R<1> and R<2> together form an aromatic or alicyclic ring or a heterocyclic group. n is an integer from 0 to 4; A represents a group selected from -CH2-, -CH=CR<9>-, -CR<9>=CH-, -CR<9>R<10>-, -CO-, -O-, -S-, -S(O)-, -S(O)2- and NR<9>, wherein R<9> and R<10> each independently represent a hydrogen atom, a straight or branched lower alkyl group, or together form an alicyclic ring; m is an integer from 0 to 8, provided that when m=0, A is not -CH2-; p is an integer from 1 to 2 and the substitution in the azonia bicyclic ring may be in the 2, 3 or 4 position including all possible configurations of the asymmetric carbons; R4 represents a group of structure: (Formulae II) wherein R<11> represents a hydrogen or halogen atom, a hydroxy group, an alkoxy group, a nitro group, a cyano group, -CO2R<12> or -NR<12>R<13>, wherein R<12> and R<13> are identical or different and are selected from hydrogen and straight or branched lower alkyl groups, or a straight or branched, substituted or unsubstituted lower alkyl group; R<5> represents an alkyl group of 1 to 7 carbon atoms, an alkenyl group containing 2 to 7 carbon atoms, or a group of formula (III) wherein q=1 or 2 and R<11> iss a defined above; R<6> represents a hydrogen atom, a hydroxy group, a methyl group or a -CH2OH group; and X<-> represents a pharmaceutically acceptable anion of a mono or polyvalent acid.
IPC 8 full level
C07D 453/02 (2006.01); A61K 31/439 (2006.01); A61K 45/00 (2006.01); A61P 1/00 (2006.01); A61P 11/00 (2006.01); A61P 13/00 (2006.01); A61P 43/00 (2006.01)
CPC (source: EP KR US)
A61P 1/00 (2018.01 - EP); A61P 1/04 (2018.01 - EP); A61P 11/00 (2018.01 - EP); A61P 13/00 (2018.01 - EP); A61P 31/06 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07D 453/02 (2013.01 - EP KR US)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 02053564 A2 20020711; WO 02053564 A3 20021031; AR 032072 A1 20031022; AT E334128 T1 20060815; AU 2002238471 B2 20070628; BG 107950 A 20040331; BG 66162 B1 20110930; BR 0116624 A 20031223; CA 2433128 A1 20020711; CA 2433128 C 20100525; CN 1250545 C 20060412; CN 1487938 A 20040407; CZ 20031812 A3 20040512; CZ 301209 B6 20091209; DE 60121813 D1 20060907; DE 60121813 T2 20070920; DK 1353919 T3 20061120; EC SP034672 A 20030829; EE 05404 B1 20110415; EE 200300312 A 20031015; EP 1353919 A2 20031022; EP 1353919 B1 20060726; ES 2266291 T3 20070301; HK 1055739 A1 20040121; HU 0303524 A2 20040128; HU 0303524 A3 20080328; IL 156558 A0 20040104; IL 156558 A 20090615; JP 2004517123 A 20040610; JP 4295985 B2 20090715; KR 100869721 B1 20081121; KR 20030067726 A 20030814; MX PA03005862 A 20050908; MY 136067 A 20080829; NO 20033002 D0 20030630; NO 20033002 L 20030630; NO 328772 B1 20100510; NZ 526674 A 20050324; PE 20020721 A1 20021001; PL 363807 A1 20041129; PT 1353919 E 20061130; RU 2003123120 A 20050110; RU 2282629 C2 20060827; SI 1353919 T1 20061231; SK 287414 B6 20100907; SK 7992003 A3 20040803; UA 75626 C2 20060515; US 2004072863 A1 20040415; US 2007105897 A1 20070510; US 2007129398 A1 20070607; US 2010234332 A1 20100916; US 7122558 B2 20061017; US 7879874 B2 20110201; US 7893087 B2 20110222; ZA 200305008 B 20050126
DOCDB simple family (application)
EP 0115168 W 20011220; AR P010106065 A 20011227; AT 01986924 T 20011220; AU 2002238471 A 20011220; BG 10795003 A 20030627; BR 0116624 A 20011220; CA 2433128 A 20011220; CN 01822242 A 20011220; CZ 20031812 A 20011220; DE 60121813 T 20011220; DK 01986924 T 20011220; EC SP034672 A 20030625; EE P200300312 A 20011220; EP 01986924 A 20011220; ES 01986924 T 20011220; HK 03108123 A 20031110; HU 0303524 A 20011220; IL 15655801 A 20011220; IL 15655803 A 20030619; JP 2002555087 A 20011220; KR 20037008651 A 20030626; MX PA03005862 A 20011220; MY PI20015907 A 20011227; NO 20033002 A 20030630; NZ 52667401 A 20011220; PE 2001001302 A 20011226; PL 36380701 A 20011220; PT 01986924 T 20011220; RU 2003123120 A 20011220; SI 200130596 T 20011220; SK 7992003 A 20011220; UA 2003066042 A 20011220; US 25044703 A 20031208; US 51459006 A 20060831; US 51533506 A 20060831; US 78534510 A 20100521; ZA 200305008 A 20030626