EP 1356070 A2 20031029 - CONDITIONALLY REPLICATING VIRAL VECTORS AND THEIR USE
Title (en)
CONDITIONALLY REPLICATING VIRAL VECTORS AND THEIR USE
Title (de)
KONDITIONELL-REPLIZIERENDE VIRALE VEKTOREN UND IHRE VERWENDUNG
Title (fr)
VECTEURS AMELIORES A REPLICATION CONDITIONNELLE, PROCEDES DE PRODUCTION ET UTILISATION DE CES VECTEURS
Publication
Application
Priority
- US 0129976 W 20010921
- US 66789300 A 20000922
Abstract (en)
[origin: WO0224897A2] The present invention provides improved conditionally replicating vectors that have improved safety against the generation of replication competent vectors or virus. Also disclosed are methods of making, propagating and selectively packaging, modifying, and using such vectors. Included are improved helper constructs, host cells, for use with the improved vectors as well as pharmaceutical compositions and host cells comprising the vectors, the use of vector containing host cells to screen drugs, and methods of using the vectors to determine gene function. The methods also include the prophylatic and therapeutic treatment of disease, especially viral infection, and HIV infection in particular.
IPC 1-7
IPC 8 full level
A61K 31/7088 (2006.01); A61K 35/76 (2006.01); A61K 48/00 (2006.01); A61P 31/12 (2006.01); A61P 31/18 (2006.01); A61P 35/00 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/867 (2006.01)
CPC (source: EP)
A61P 31/12 (2017.12); A61P 31/18 (2017.12); A61P 35/00 (2017.12); C12N 15/86 (2013.01); A61K 48/00 (2013.01); C12N 2740/16043 (2013.01); C12N 2800/108 (2013.01); C12N 2830/40 (2013.01); C12N 2830/42 (2013.01); C12N 2830/48 (2013.01); C12N 2830/50 (2013.01); C12N 2840/20 (2013.01); C12N 2840/203 (2013.01); C12N 2840/44 (2013.01)
Citation (search report)
See references of WO 0224897A2
Citation (examination)
- AN D.S. ET AL: "An inducible human immunodeficiency virus type 1 (HIV-1) vector hich effectively suppresses HIV-1 replication", JOURNAL OF VIROLOGY, vol. 73, no. 9, September 1999 (1999-09-01), pages 7671 - 7677, XP002320208
- KOTSOPOULOU E. ET AL: "A rev-independent human immunodeficiency virus type 1 (HIV-1)-based vector that exploits a codon-optimized HIV-1 gag-pol gene", JOURNAL OF VIROLOGY, vol. 74, no. 10, May 2000 (2000-05-01), pages 4839 - 4852, XP002152133, DOI: doi:10.1128/JVI.74.10.4839-4852.2000
- DICKIE P. ET AL: "Models of HIV type 1 proviral gene expression in wild-type HIV1 and MLV/HIV transgenic mice", AIDS RESEARCH AND HUMAN RETROVIRUSES, vol. 12, no. 12, 1996, pages 1103 - 1116, XP002907029
- MAUTINO M.R. ET AL: "Modified human immunodeficiency virus-based lentiviral vectors display decreased sensitivity to trans-dominant rev", HUMAN GENE THERAPY, vol. 11, April 2000 (2000-04-01), pages 895 - 908
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0224897 A2 20020328; WO 0224897 A3 20030731; WO 0224897 A9 20030320; AU 9307501 A 20020402; CA 2422544 A1 20020328; CZ 2003784 A3 20031112; EP 1356070 A2 20031029; IL 154987 A0 20031031; JP 2004524813 A 20040819; NO 20031293 D0 20030320; NO 20031293 L 20030514; NZ 525283 A 20080630; RU 2301260 C2 20070620
DOCDB simple family (application)
US 0129976 W 20010921; AU 9307501 A 20010921; CA 2422544 A 20010921; CZ 2003784 A 20010921; EP 01973503 A 20010921; IL 15498701 A 20010921; JP 2002529492 A 20010921; NO 20031293 A 20030320; NZ 52528301 A 20010921; RU 2003111469 A 20010921