Title (en)

CYCLIC 2-CARBONYLAMINOKETONES AS INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES

Title (de)

CYCLISCHE 2-CARBONYLAMINOKETONE ALS INHIBITOREN VON CRUZIPAIN UND ANDEREN CYSTEINPROTEASEN

Title (fr)

2-CARBONYLAMINOCETONES CYCLIQUES, INHIBITEURS DE LA CRUZIPAIN ET AUTRES CYSTEINE PROTEASES

Publication

EP 1362042 A1 20031119 (EN)

Application

EP 02732147 A 20020117

Priority

• GB 0200190 W 20020117
• GB 0101187 A 20010117
• US 27550501 P 20010313

Abstract (en)

[origin: WO02057249A1] Compounds of general formula (I), wherein R<1>, R<2>, R<3>, Y, (X)o, (W)n, (V)m, Z and U are as defined in the specification, are inhibitors of cruzipain and other cysteine protease inhibitors and are useful as therapeutic agents, for example in Chagas' disease, or for validating therapeutic target compounds.

IPC 1-7

C07D 307/32; C07D 409/12; C07D 409/14; C07D 417/14; A61K 31/34; A61P 33/00

IPC 8 full level

A61K 31/341 (2006.01); A61K 31/4439 (2006.01); A61K 31/5377 (2006.01); A61P 33/00 (2006.01); A61P 33/02 (2006.01); A61P 43/00 (2006.01); C07D 307/32 (2006.01); C07D 307/33 (2006.01); C07D 307/68 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01); C07D 409/14 (2006.01); C07D 417/14 (2006.01)

CPC (source: EP)

A61K 31/341 (2013.01); A61K 31/4439 (2013.01); A61P 33/00 (2017.12); A61P 33/02 (2017.12); A61P 43/00 (2017.12); C07D 307/32 (2013.01); C07D 307/68 (2013.01); C07D 405/12 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01); C07D 417/14 (2013.01); Y02A 50/30 (2017.12)

Citation (search report)

See references of WO 02057249A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

WO 02057249 A1 20020725; CA 2435117 A1 20020725; EP 1362042 A1 20031119; IL 156775 A0 20040208; JP 2004522738 A 20040729; NZ 526914 A 20050225

DOCDB simple family (application)

GB 0200190 W 20020117; CA 2435117 A 20020117; EP 02732147 A 20020117; IL 15677502 A 20020117; JP 2002557930 A 20020117; NZ 52691402 A 20020117