EP 1362926 A1 20031119 - Human obesity susceptibility gene and uses thereof
Title (en)
Human obesity susceptibility gene and uses thereof
Title (de)
Humanes fettleibigkeit Suszeptibilitätsgen und deren Verwendungen
Title (fr)
Gène humain de susceptibilité à l'obésité et leurs utilisations
Publication
Application
Priority
EP 02291201 A 20020515
Abstract (en)
The present invention discloses the identification of a human obesity susceptibility gene, which can be used for the diagnosis, prevention and treatment of obesity and related disorders, as well as for the screening of therapeutically active drugs. The invention more specifically discloses that the PPYR1 gene on chromosome 10 and certain alleles thereof are related to susceptibility to obesity and represent novel targets for therapeutic intervention. The present invention relates to particular mutations in the PPYR1 gene and expression products, as well as to diagnostic tools and kits based on these mutations. The invention can be used in the diagnosis of predisposition to, detection, prevention and/or treatment of coronary heart disease and metabolic disorders, including hypoalphalipoproteinemia, familial combined hyperlipidemia, insulin resistant syndrome X or multiple metabolic disorder, coronary artery disease, diabetes and dyslipidemic hypertension. <IMAGE>
IPC 1-7
IPC 8 full level
C12Q 1/68 (2006.01)
CPC (source: EP)
C12Q 1/6883 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/158 (2013.01)
Citation (search report)
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- [A] NELSON STANLEY F ET AL: "Genomic mismatch scannings: A new approach to genetic linkage mapping.", NATURE GENETICS, vol. 4, no. 1, 1993, pages 11 - 18, XP000606264, ISSN: 1061-4036
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Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
DOCDB simple family (application)
EP 02291201 A 20020515