EP 1363624 A2 20031126 - FLUORO OXINDOLE DERIVATIVES AS MODULATORS OF KCNQ POTASSIUM CHANNELS
Title (en)
FLUORO OXINDOLE DERIVATIVES AS MODULATORS OF KCNQ POTASSIUM CHANNELS
Title (de)
FLUOROXINDOL-DERIVATE ALS MODULATOREN DER KCNQ-KALIUM-KANÄLEN
Title (fr)
DERIVES DE FLUORO OXINDOLE EN TANT QUE MODULATEURS DE CANAUX POTASSIUM KCNQ
Publication
Application
Priority
- US 0204304 W 20020214
- US 27011201 P 20010220
Abstract (en)
[origin: WO02066426A2] There is provided novel 3-fluoro-3-phenyl oxindole derivatives of Formula I wherein R<1>, R<2>, R<3> and R<4> each are independently hydrogen, C1-4 alkyl, halogen, fluoromethyl, trifluoromethyl, phenyl, 4-methylphenyl or 4-trifluoromethylphenyl; R<5> is C1-6 alkyl optionally substituted with one to three same or different groups selected from fluoro and chloro, provided R<5> is not C1-6 alkyl when Y is O; Y is O or S; and R<6> and R<7> each are independently hydrogen, chloro, bromo or trifluoromethy; which are openers of the KCNQ potassium channels and are useful in the treatment of disorders which are responsive to the opening of the KCNQ potassium channels.
IPC 1-7
IPC 8 full level
A61P 25/06 (2006.01); A61K 31/404 (2006.01); A61P 43/00 (2006.01); C07D 209/34 (2006.01)
CPC (source: EP)
A61P 25/06 (2018.01); A61P 43/00 (2018.01); C07D 209/34 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 02066426 A2 20020829; WO 02066426 A3 20021121; CA 2438805 A1 20020829; EP 1363624 A2 20031126; HU P0400063 A2 20040428; JP 2004531483 A 20041014
DOCDB simple family (application)
US 0204304 W 20020214; CA 2438805 A 20020214; EP 02714888 A 20020214; HU P0400063 A 20020214; JP 2002565943 A 20020214