EP 1364958 B1 20100908 - GLYCOPYRANOSYLOXYPYRAZOLE DERIVATIVES AND MEDICINAL USE THEREOF
Title (en)
GLYCOPYRANOSYLOXYPYRAZOLE DERIVATIVES AND MEDICINAL USE THEREOF
Title (de)
GLYKOPYRANOSYLOXYPYRAZOLDERIVATE UND DEREN MEDIZINISCHE VERWENDUNG
Title (fr)
DERIVES DE GLYCOPYRANOSYLOXYPYRAZOLE ET UTILISATION MEDICINALE DE CEUX-CI
Publication
Application
Priority
- JP 0201708 W 20020226
- JP 2001053085 A 20010227
Abstract (en)
[origin: EP1364958A1] The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: <CHEM> wherein R<1>, R<2> and R<3> represent a hydrogen atom or a halogen atom; R<4> represents a lower alkyl group or a halo(lower alkyl) group; and R<5> represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, etc., a pharmaceutically acceptable salt thereof or a prodrug thereof., which exert an excellent inhibitory activity in human SGLT2, and therefore are useful as drugs for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, pharmaceutically acceptable salts thereof or prodrugs thereof, production intermediates thereof and pharmaceutical uses thereof.
IPC 8 full level
A61K 31/70 (2006.01); A61P 3/04 (2006.01); A61P 3/06 (2006.01); A61P 3/10 (2006.01); A61P 7/10 (2006.01); A61P 9/04 (2006.01); A61P 9/10 (2006.01); A61P 9/12 (2006.01); A61P 19/06 (2006.01); A61P 43/00 (2006.01); C07D 231/20 (2006.01); C07D 233/70 (2006.01); C07H 17/02 (2006.01)
CPC (source: EP US)
A61P 3/04 (2017.12 - EP); A61P 3/06 (2017.12 - EP); A61P 3/10 (2017.12 - EP); A61P 7/10 (2017.12 - EP); A61P 9/04 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 9/12 (2017.12 - EP); A61P 19/06 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07H 17/02 (2013.01 - EP US)
Designated contracting state (EPC)
BE DE ES FR GB IT
DOCDB simple family (publication)
EP 1364958 A1 20031126; EP 1364958 A4 20040414; EP 1364958 B1 20100908; CA 2438595 A1 20020906; CA 2438595 C 20110809; DE 60237580 D1 20101021; ES 2350084 T3 20110118; JP 4147111 B2 20080910; JP WO2002068440 A1 20040624; TW I249535 B 20060221; US 2004116357 A1 20040617; US 7294618 B2 20071113; WO 02068440 A1 20020906
DOCDB simple family (application)
EP 02703898 A 20020226; CA 2438595 A 20020226; DE 60237580 T 20020226; ES 02703898 T 20020226; JP 0201708 W 20020226; JP 2002567950 A 20020226; TW 91103572 A 20020227; US 46914004 A 20040112