EP 1366061 A4 20060426 - METHOD OF TREATING AMYLOID BETA PRECURSOR DISORDERS
Title (en)
METHOD OF TREATING AMYLOID BETA PRECURSOR DISORDERS
Title (de)
VERFAHREN ZUR BEHANDLUNG VON BETA-AMYLOID-PRECURSOR-ERKRANKUNGEN
Title (fr)
METHODE DE TRAITEMENT DE TROUBLES DE LA MATURATION DU PRECURSEUR DE LA PROTEINE BETA AMYLOIDE
Publication
Application
Priority
- US 0203256 W 20020205
- US 26588601 P 20010205
Abstract (en)
[origin: WO02062824A2] Methods for the treatment and prevention of APP processing disorders such as Alzheimer's disease and Down's Syndrome which are based on the administration of an effective amount of a HMG-CoA reductase inhibitor to a mammal are disclosed. Additionally, methods for the treatment and prevention of APP processing disorders such as Alzheimer's disease and Down's Syndrome which are based on the reduction of cellular cholesterol in a mammal are disclosed. These methods reduce the amount of A beta peptides or decrease the formation of A beta peptides or increase the clearance of A beta peptides in a mammal suffering from Alzheimer's disease and Down's Syndrome.
IPC 1-7
IPC 8 full level
A61K 31/00 (2006.01); A61K 31/192 (2006.01); A61K 31/22 (2006.01); A61K 31/366 (2006.01); A61K 31/40 (2006.01); A61K 31/401 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP)
A61K 31/00 (2013.01); A61K 31/192 (2013.01); A61K 31/22 (2013.01); A61K 31/366 (2013.01); A61K 31/40 (2013.01); A61K 31/401 (2013.01); G01N 33/6896 (2013.01)
Citation (search report)
- [PX] WO 0132161 A2 20010510 - ANDRX CORP [US]
- [X] WO 9948488 A2 19990930 - CHILDRENS MEDICAL CENTER [US]
- [X] EP 0783104 A1 19970709 - ORIENTAL YEAST CO LTD [JP]
- [X] WO 0031548 A1 20000602 - SCIOS INC [US], et al
- [X] WO 9506470 A1 19950309 - MERCK & CO INC [US], et al
- [X] WO 9938498 A1 19990805 - WARNER LAMBERT CO [US], et al
- [X] WO 0028981 A2 20000525 - NYMOX CORP [CA], et al
- [X] WO 9921978 A1 19990506 - MIRIAM HOSPITAL A LIFESPAN PAR [US], et al
- [X] WO 9748391 A2 19971224 - ADVANCED RES & TECH INST [US], et al
- [X] WO 9819169 A1 19980507 - UNIV BOSTON [US]
- [X] WO 9813488 A2 19980402 - SCHERING AG [DE], et al & SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 27, no. 2, 2001, 31ST ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE; SAN DIEGO, CALIFORNIA, USA; NOVEMBER 10-15, 2001, pages 1718, ISSN: 0190-5295 & SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 26, no. 1-2, 2000, 30TH ANNUAL MEETING OF THE SOCIETY OF NEUROSCIENCE; NEW ORLEANS, LA, USA; NOVEMBER 04-09, 2000, pages Abstract No. - 763.13, ISSN: 0190-5295 & NEUROBIOLOGY OF AGING 1998 UNITED STATES, vol. 19, no. 3, 1998, pages 201 - 204, ISSN: 0197-4580
- [X] DOVEY H F ET AL: "FUNCTIONAL GAMMA-SECRETASE INHIBITORS REDUCE BETA-AMYLOID PEPTIDE LEVELS IN BRAIN", JOURNAL OF NEUROCHEMISTRY, NEW YORK, NY, US, vol. 76, no. 1, January 2001 (2001-01-01), pages 173 - 181, XP001147446, ISSN: 0022-3042
- [PX] DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 2001, WESTERMAN M A ET AL: "Ibuprofen as a treatment of cognitive decline in the Tg2576 mouse model of Alzheimer's disease", XP002369757, Database accession no. PREV200100563487
- [PX] DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 2000, YANG L B ET AL: "Amyloid beta peptide (Abeta) induced TNF-alpha release from Alzheimer microglia is inhibited by diclofenac, an anti-inflammatory drug", XP002369758, Database accession no. PREV200100121209
- [X] DATABASE EMBASE [online] ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL; 1998, NETLAND E E ET AL: "Indomethacin reverses the microglial response to amyloid [beta]-protein", XP002369759, Database accession no. EMB-1998240403
- See references of WO 02062824A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 02062824 A2 20020815; WO 02062824 A3 20021121; CA 2437480 A1 20020815; EP 1366061 A2 20031203; EP 1366061 A4 20060426
DOCDB simple family (application)
US 0203256 W 20020205; CA 2437480 A 20020205; EP 02718903 A 20020205