EP 1368338 A1 20031210 - METHOD OF PREPARING LANSOPRAZOLE AND ITS INTERMEDIATE
Title (en)
METHOD OF PREPARING LANSOPRAZOLE AND ITS INTERMEDIATE
Title (de)
VERFAHREN ZUR HERSTELLUNG VON LANSOPRAZOL UND DESSEN ZWISCHENPRODUKT
Title (fr)
PROCEDE DE PREPARATION DE LANSOPRAZOLE ET DE SON INTERMEDIAIRE
Publication
Application
Priority
- KR 0200261 W 20020220
- KR 20010008677 A 20010221
Abstract (en)
[origin: WO02074766A1] The present invention relates to a process for preparing lansoprazole of the following formula (I) and its intermediate, 2-[3-methyl-4(2,2,2-trifluoroethoxy)-2-pyridil]methylthio-1H-benzimidazole of the following formula (II), which comprises reacting 2-hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy) pyridine or its salt with 2-mercaptobenzimidazole in the presence of a halogenating agent and reaction solvent, and then oxidizing the resulting compound (II) with hydrogen peroxide in the presence of a benzeneseleninic acid catalyst and reaction solution to obtain lansoprazole(I).
IPC 1-7
IPC 8 full level
A61K 31/4439 (2006.01); A61P 1/04 (2006.01); C07B 61/00 (2006.01); C07D 401/12 (2006.01)
CPC (source: EP KR)
A61P 1/04 (2017.12 - EP); C07D 401/12 (2013.01 - EP KR)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 02074766 A1 20020926; EP 1368338 A1 20031210; EP 1368338 A4 20040915; JP 2004525927 A 20040826; KR 100430575 B1 20040510; KR 20020068592 A 20020828
DOCDB simple family (application)
KR 0200261 W 20020220; EP 02700866 A 20020220; JP 2002573775 A 20020220; KR 20010008677 A 20010221