EP 1370287 A2 20031217 - METHOD AND COMPOSITION FOR MODULATING BONE GROWTH
Title (en)
METHOD AND COMPOSITION FOR MODULATING BONE GROWTH
Title (de)
VERFAHREN UND ZUSAMMENSETZUNG ZUR MODULATION VON KNOCHENWACHSTUM
Title (fr)
METHODE ET COMPOSITION PERMETTANT DE MODULER LA CROISSANCE OSSEUSE
Publication
Application
Priority
- US 0146291 W 20011203
- US 25053500 P 20001201
Abstract (en)
[origin: WO0243759A2] Methods and compositions are provided for the treatment of defects and disease involving osteoporosis, or osteopenic conditions. The methods comprises applying to the site of osteoporotic or osteopenic conditions a composition comprising a BMP-3 inhibitor or antagonist. The invention further provides methods and compositions for modulating or regulating the formation of bone utilizing BMP-3 compositions.
IPC 1-7
A61K 39/395; A61K 31/7088; G01N 33/50; A61K 9/00; A61P 19/10
IPC 8 full level
A61P 19/10 (2006.01); C07K 14/51 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 19/10 (2017.12); C07K 14/51 (2013.01); A61K 38/00 (2013.01); C12N 2799/027 (2013.01)
Citation (search report)
See references of WO 0243759A2
Citation (examination)
- DALUISKI A ET AL: "Bone morphogenic protein-3 is a negative regulator of bone density", NATURE GENETICS, vol. 27, 2001, pages 84 - 88
- GAMER L ET AL: "bmp-3 is a novel inhibitor of both activin and BMP-4 signaling in Xenopus embryos", DEVELOPMENTAL BIOLOGY, vol. 285, 2005, pages 156 - 168, XP005015206, DOI: doi:10.1016/j.ydbio.2005.06.012
- LIEBERMAN J ET AL: "The effect of regional gene therapy with bone morphogenic protein-2 producing bone-marrow cells on the repair of segmental femoral defects in rats", THE JOURNAL OF BONE AND JOINT SURGERY, vol. 81-a, no. 7, 1999, pages 905 - 917, XP001149972
- DONALDSON C ET AL: "Activin and inhibin binding to the soluble extracellular domain of activin receptor II", ENDOCRINOLOGY, vol. 140, no. 4, 1999, pages 1760 - 1766, XP002366135, DOI: doi:10.1210/en.140.4.1760
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0243759 A2 20020606; WO 0243759 A3 20031009; AU 3655802 A 20020611; EP 1370287 A2 20031217
DOCDB simple family (application)
US 0146291 W 20011203; AU 3655802 A 20011203; EP 01986092 A 20011203