Global Patent Index - EP 1370287 A2

EP 1370287 A2 20031217 - METHOD AND COMPOSITION FOR MODULATING BONE GROWTH

Title (en)

METHOD AND COMPOSITION FOR MODULATING BONE GROWTH

Title (de)

VERFAHREN UND ZUSAMMENSETZUNG ZUR MODULATION VON KNOCHENWACHSTUM

Title (fr)

METHODE ET COMPOSITION PERMETTANT DE MODULER LA CROISSANCE OSSEUSE

Publication

EP 1370287 A2 20031217 (EN)

Application

EP 01986092 A 20011203

Priority

  • US 0146291 W 20011203
  • US 25053500 P 20001201

Abstract (en)

[origin: WO0243759A2] Methods and compositions are provided for the treatment of defects and disease involving osteoporosis, or osteopenic conditions. The methods comprises applying to the site of osteoporotic or osteopenic conditions a composition comprising a BMP-3 inhibitor or antagonist. The invention further provides methods and compositions for modulating or regulating the formation of bone utilizing BMP-3 compositions.

IPC 1-7

A61K 39/395; A61K 31/7088; G01N 33/50; A61K 9/00; A61P 19/10

IPC 8 full level

A61P 19/10 (2006.01); C07K 14/51 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP)

A61P 19/10 (2017.12); C07K 14/51 (2013.01); A61K 38/00 (2013.01); C12N 2799/027 (2013.01)

Citation (search report)

See references of WO 0243759A2

Citation (examination)

  • DALUISKI A ET AL: "Bone morphogenic protein-3 is a negative regulator of bone density", NATURE GENETICS, vol. 27, 2001, pages 84 - 88
  • GAMER L ET AL: "bmp-3 is a novel inhibitor of both activin and BMP-4 signaling in Xenopus embryos", DEVELOPMENTAL BIOLOGY, vol. 285, 2005, pages 156 - 168, XP005015206, DOI: doi:10.1016/j.ydbio.2005.06.012
  • LIEBERMAN J ET AL: "The effect of regional gene therapy with bone morphogenic protein-2 producing bone-marrow cells on the repair of segmental femoral defects in rats", THE JOURNAL OF BONE AND JOINT SURGERY, vol. 81-a, no. 7, 1999, pages 905 - 917, XP001149972
  • DONALDSON C ET AL: "Activin and inhibin binding to the soluble extracellular domain of activin receptor II", ENDOCRINOLOGY, vol. 140, no. 4, 1999, pages 1760 - 1766, XP002366135, DOI: doi:10.1210/en.140.4.1760

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

WO 0243759 A2 20020606; WO 0243759 A3 20031009; AU 3655802 A 20020611; EP 1370287 A2 20031217

DOCDB simple family (application)

US 0146291 W 20011203; AU 3655802 A 20011203; EP 01986092 A 20011203