EP 1370567 A2 20031217 - METHOD FOR THE PRODUCTION OF PENTOPYRANOSYL NUCLEOSIDES
Title (en)
METHOD FOR THE PRODUCTION OF PENTOPYRANOSYL NUCLEOSIDES
Title (de)
VERFAHREN ZUR HERSTELLUNG VON PENTOPYRANOSYL-NUCLEOSIDEN
Title (fr)
PROCEDE DE PRODUCTION DE NUCLEOSIDES DE PENTOPYRANOSYLE
Publication
Application
Priority
- DE 10111681 A 20010309
- EP 0202536 W 20020307
Abstract (en)
[origin: WO02072595A2] The invention relates to an improved method for the production of pentopyranosyl nucleosides, in which a significant improvement and simplification of the method steps described in DE-A-19741715 can be achieved. According to the invention, a migration of the 2' acyl protecting group, from the 2' position to the 3' position of the pentopyranoside can be achieved by the application of a catalyst of formula (IVa) or (IVb), where A = -CH>2<-, -NR?20>-,R<20>, H, optionally substituted alkyl, cycloalkyl, aryl or aralkyl, D = a group of formula CmH2m-, m = a whole number from 1 to 6, R<18>, R<19> and R<24> independently = H, optionally substituted alkyl, cycloalkyl, aryl or aralkyl, or R<18> and R<19> together represent a -CoH2o- group, where o = a whole number from 2 to 4 and R<21> = a NR<22>R<23> group, where R<22> and R<23> independently = H, optionally substituted alkyl, cycloalkyl, aryl or aralkyl.
IPC 1-7
IPC 8 full level
C07H 19/06 (2006.01); C07H 19/16 (2006.01)
CPC (source: EP US)
C07H 19/06 (2013.01 - EP US); C07H 19/16 (2013.01 - EP US); Y02P 20/55 (2015.11 - EP US)
Citation (search report)
See references of WO 02072595A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 02072595 A2 20020919; WO 02072595 A3 20030123; AU 2002251062 A1 20020924; DE 10111681 A1 20021002; EP 1370567 A2 20031217; US 2004068107 A1 20040408
DOCDB simple family (application)
EP 0202536 W 20020307; AU 2002251062 A 20020307; DE 10111681 A 20010309; EP 02719986 A 20020307; US 46907303 A 20030826