EP 1370874 A2 20031217 - METHODS FOR DETERMINING PLATELET ACTIVITY WITH ANTIPLATELET COMPOSITIONS
Title (en)
METHODS FOR DETERMINING PLATELET ACTIVITY WITH ANTIPLATELET COMPOSITIONS
Title (de)
VERFAHREN ZUR BESTIMMUNG DER PLÄTTCHEN-AKTIVITÄT UNTER VERWENDUNG VON ANTI-PLÄTTCHEN-ZUSAMMENSETZUNGEN
Title (fr)
METHODES PERMETTANT DE DETERMINER L'ACTIVITE DES PLAQUETTES A L'AIDE DE COMPOSITIONS ANTI-PLAQUETTES
Publication
Application
Priority
- US 0202102 W 20020123
- US 26383801 P 20010124
Abstract (en)
[origin: WO02059623A2] Methods, compositions and kits are disclosed for the determination of platelet activity on samples such as whole blood that have been affected by exposure to an antiplatelet therapeutic agent such as, <i>e.g.</i>, aspiring or a thienopyridine. A combination is provided in a reaction medium wherein the combination comprises the sample and a particle reagent comprising a GP IIb/IIIa receptor ligand such as fibrinogen covalently attached to particles. The medium further comprises a polyhydroxy aromatic compound and a metal cation. The combination is incubated under conditions for agglutinating the particles. The extent of agglutination of the particles is determined and is related to the platelet function activity of the sample. The methods and compositions have particular application to the detection of platelet sensitivity to therapy using aspirin or a thienopyridine and the assessment of the efficacy of such therapy.
IPC 1-7
IPC 8 full level
G01N 33/80 (2006.01); G01N 33/86 (2006.01)
CPC (source: EP)
G01N 33/80 (2013.01); G01N 33/86 (2013.01); G01N 2800/52 (2013.01)
Citation (search report)
See references of WO 02059623A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 02059623 A2 20020801; WO 02059623 A3 20030220; WO 02059623 A8 20031218; EP 1370874 A2 20031217
DOCDB simple family (application)
US 0202102 W 20020123; EP 02703225 A 20020123