EP 1373299 A4 20050119 - CONNECTIVE TISSUE GROWTH FACTOR-2
Title (en)
CONNECTIVE TISSUE GROWTH FACTOR-2
Title (de)
BINDEGEWEBS-WACHSTUMSFAKTOR-2
Title (fr)
FACTEUR DE CROISSANCE 2 DE TISSU CONJONCTIF
Publication
Application
Priority
- US 0121799 W 20010711
- US 21740200 P 20000711
- US 29164201 P 20010518
Abstract (en)
[origin: WO0204480A2] The present invention relates to a human CTGH-2 polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist/inhibitors against such polypeptide. Also provided are methods of using the polypeptide therapeutically for stimulating angiogenesis enhancing the repair of connective and support tissue, promoting the attachment, fixation and stabilization of tissue implants and enhancing wound healing. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
IPC 1-7
IPC 8 full level
C07K 14/475 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); C07K 14/475 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
- [X] WO 9733995 A2 19970918 - MUNIN CORP [US], et al
- [X] BABIC A M ET AL: "CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 95, May 1998 (1998-05-01), pages 6355 - 6360, XP002175432, ISSN: 0027-8424
- [X] XIE D ET AL: "CYR61, an angiogenic inducer, is over-expressed and estrogen inducible in breast cancer", PROCEEDINGS OF THE 91ST ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. SAN FRANCISCO, CA, APRIL 1 - 5, 2000, PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, PHILADELPHIA, PA : AACR, US, vol. VOL. 41, 1 April 2000 (2000-04-01), pages 338, XP002194654
- [X] BABIC A M ET AL: "Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo", MOLECULAR AND CELLULAR BIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, US, vol. 19, no. 4, April 1999 (1999-04-01), pages 2958 - 2966, XP002284941, ISSN: 0270-7306
- [X] JEDSADAYANMATA A ET AL: "Activation-dependent Adhesion of Human Platelets to Cyr61 and Fisp12/Mouse Conective Tissue Growth Factor Is Mediated through Integrin alphaIIbbeta3", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 274, no. 34, 20 August 1999 (1999-08-20), pages 24321 - 24327, XP002175431, ISSN: 0021-9258
- [A] SHIMO T ET AL: "INHIBITION OF ENDOGENOUS EXPRESSION OF CONNECTIVE TISSUE GROWTH FACTOR BY ITS ANTISENSE OLIGONUCLEOTIDE AND ANTISENSE RNA SUPPRESSES PROLIFERATION AND MIGRATION OF VASCULAR ENDOTHELIAL CELLS", JOURNAL OF BIOCHEMISTRY, JAPANESE BIOCHEMICAL SOCIETY, TOKYO, JP, vol. 124, no. 1, July 1998 (1998-07-01), pages 130 - 140, XP009009314, ISSN: 0021-924X
- See references of WO 0204480A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0204480 A2 20020117; WO 0204480 A3 20031016; AU 7686801 A 20020121; CA 2412124 A1 20020117; EP 1373299 A2 20040102; EP 1373299 A4 20050119
DOCDB simple family (application)
US 0121799 W 20010711; AU 7686801 A 20010711; CA 2412124 A 20010711; EP 01954638 A 20010711