Global Patent Index - EP 1373498 A2

EP 1373498 A2 20040102 - ANIMAL TISSUE WITH CARBOHYDRATE ANTIGENS COMPATIBLE FOR HUMAN TRANSPLANTATION

Title (en)

ANIMAL TISSUE WITH CARBOHYDRATE ANTIGENS COMPATIBLE FOR HUMAN TRANSPLANTATION

Title (de)

TIERISCHES GEWEBE MIT KOHLENHYDRATANTIGENEN GEEIGNET FÜR DIE HUMANTRANSPLANTATION

Title (fr)

TISSU ANIMAL COMPORTANT DES ANTIGENES CARBOHYDRATES COMPATIBLES EN VUE D'UNE GREFFE HUMAINE

Publication

EP 1373498 A2 20040102 (EN)

Application

EP 02708083 A 20020321

Priority

  • CA 0200378 W 20020321
  • US 27781101 P 20010321

Abstract (en)

[origin: WO02074948A2] This disclosure provides a system for generating animal tissue with carbohydrate antigens that are compatible for transplantation into human patients. The tissue is inactivated homozygously for expression of alpha (1,3)galactosyltransferase, and comprises a transgene for alpha (1,2)fucosyltransferase. As a result, cell-surface N-acetyl lactosamine is not converted to the Gal alpha (1,3)Gal xenoantigen. Instead, it is converted to Fuc alpha (1,2)Gal, which is H substance, a self-antigen in humans. The tissue may also contain A or B-transferase, which will cause H substance to be converted into other ABO blood group antigens for compatibility with patients of the same blood type. This invention improves transplant compatibility of the xenograft tissue by lessening the risk of reactions resulting from xenoantigen and unconverted N-acetyl lactosamine acceptor determinants.

IPC 1-7

C12N 15/06; A01K 67/027; C12N 5/06

IPC 8 full level

A01K 67/027 (2006.01); C12N 9/10 (2006.01); C12N 15/06 (2006.01); C12N 15/85 (2006.01); A61K 35/12 (2006.01)

CPC (source: EP)

A01K 67/0271 (2013.01); A01K 67/0276 (2013.01); C12N 9/1051 (2013.01); C12N 15/8509 (2013.01); A01K 2217/075 (2013.01); A01K 2227/105 (2013.01); A01K 2267/02 (2013.01); A01K 2267/025 (2013.01); A61K 2035/122 (2013.01); C12N 2517/02 (2013.01); C12N 2517/04 (2013.01); C12N 2800/108 (2013.01); C12N 2800/30 (2013.01)

Citation (search report)

See references of WO 02074948A2

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

WO 02074948 A2 20020926; WO 02074948 A3 20021114; AU 2002242538 B2 20070628; EP 1373498 A2 20040102

DOCDB simple family (application)

CA 0200378 W 20020321; AU 2002242538 A 20020321; EP 02708083 A 20020321