EP 1373888 A2 20040102 - METHOD FOR SCREENING FOR PROGESTERONE RECEPTOR ISOFORM-SPECIFIC LIGANDS
Title (en)
METHOD FOR SCREENING FOR PROGESTERONE RECEPTOR ISOFORM-SPECIFIC LIGANDS
Title (de)
METHODE ZUM AUFFINDEN VON LIGANDEN FÜR DIE ISOFORMEN DES PROGESTERON-REZEPTORS
Title (fr)
PROCEDE DE CRIBLAGE DE LIGANDS A SPECIFICITE POUR L'ISOFORME DES RECEPTEURS DE PROGESTERONE
Publication
Application
Priority
- EP 0115200 W 20011221
- US 25831200 P 20001228
- US 30587501 P 20010718
Abstract (en)
[origin: WO02054064A2] The present invention provides a method for screening for progesterone receptor isoform specific ligands as well as a first method for screening for tissue-selective progesterone receptor ligands, both methods comprising selecting progesterone receptor isoform A or progesterone receptor isoform B selective ligands by means of an assay involving cells stably transfected with plasmids expressing the progesterone receptor isoform A or B. Furthermore, the present invention provides a second method for screening for tissue-selective progesterone receptor ligands, comprising in vivo tests in desired target tissues. The present invention also relates to the progesterone receptor isoform specific and/or tissue-selective ligands identified through the methods according to the present invention. The present invention further relates to cell lines suitable for this transactivation assay, a respective assay kit and medical uses of the isoform-specific and/or tissue-selective progesterone receptor ligands according to the present invention.
IPC 1-7
IPC 8 full level
A61K 45/00 (2006.01); A61P 5/30 (2006.01); A61P 15/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12Q 1/02 (2006.01); C12Q 1/66 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/53 (2006.01); G01N 33/566 (2006.01); G01N 33/74 (2006.01)
CPC (source: EP)
A61P 5/24 (2017.12); A61P 5/30 (2017.12); A61P 15/00 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); G01N 33/5008 (2013.01); G01N 33/5011 (2013.01); G01N 33/502 (2013.01); G01N 33/5044 (2013.01); G01N 33/5088 (2013.01); G01N 33/743 (2013.01); G01N 2333/723 (2013.01)
Citation (search report)
See references of WO 02054064A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 02054064 A2 20020711; WO 02054064 A3 20031016; AR 032050 A1 20031022; AU 2002219218 A1 20020716; EP 1373888 A2 20040102; JP 2004516841 A 20040610; NO 20032969 D0 20030627; NO 20032969 L 20030828; PE 20020784 A1 20021003; UY 27107 A1 20020322
DOCDB simple family (application)
EP 0115200 W 20011221; AR P010106030 A 20011226; AU 2002219218 A 20011221; EP 01272662 A 20011221; JP 2002554712 A 20011221; NO 20032969 A 20030627; PE 2001001311 A 20011228; UY 27107 A 20011228