Global Patent Index - EP 1378521 A1

EP 1378521 A1 20040107 - Anti-Carbohydrate Deficient Transferrin (CDT) spezific antibody, its production and use

Title (en)

Anti-Carbohydrate Deficient Transferrin (CDT) spezific antibody, its production and use

Title (de)

Carbohydrate Deficient Transferrin (CDT)-spezifische Antikörper, ihre Herstellung und Verwendung

Title (fr)

Anticorps spécifique pour le Carbohydrate Deficient Transferrin (CDT), sa production et utilisation

Publication

EP 1378521 A1 20040107 (DE)

Application

EP 03011334 A 20030519

Priority

DE 10230550 A 20020705

Abstract (en)

Antibody (Ab) that, in aqueous solution, binds selectively to carbohydrate-deficient transferrin (CDT) without having to bind CDT to a solid phase. Independent claims are also included for the following: (1) antibody (Ab1) that binds selectively to CDT at regions (1)-(4) (single-letter amino acid code): VVARSMGGKEDLIWELL (1); TTEDSIAKIMNGEADAMSLDGGF (2); SKLSMGSGLNLSEPN (3) and YEKYLGEEYVKAV (4); (2) antigen-binding fragments of Ab and Ab1; (3) methods for preparing Ab and Ab1; (4) immunoassay for detecting CDT using Ab or Ab1, or their fragments; and (5) test kit for method (3).

Abstract (de)

Die vorliegende Erfindung betrifft Antikörper, die in wäßriger Lösung selektiv an ein Transferrin-Homologes "Carbohydrate Deficient Transferrin" (CDT) binden, ohne daß dieses an eine feste Phase gebunden zu sein braucht. CDT ist dadurch gekennzeichnet, daß mindestens eine der zwei Oligosaccharidketten, die normalerweise an Asn 413 und/oder Asn 611 des Transferrins gebunden sind, ganz oder im wesentlichen ganz fehlen.

IPC 1-7

C07K 16/18; G01N 33/536; G01N 33/98

IPC 8 full level

C07K 16/18 (2006.01); G01N 33/68 (2006.01)

CPC (source: EP)

C07K 16/18 (2013.01); G01N 33/6842 (2013.01); C07K 2317/33 (2013.01); C07K 2317/34 (2013.01); G01N 2333/79 (2013.01)

Citation (search report)

  • [X] WO 9306133 A1 19930401 - MAKHLOUF SAMAR [US], et al
  • [X] WO 0036418 A1 20000622 - AXIS SHIELD ASA [NO], et al
  • [X] WO 9900672 A1 19990107 - AXIS BIOCHEMICALS ASA [NO], et al
  • [A] TRIMBLE ESTHER R ET AL: "Anti-peptide antibodies to epitopes masked by the carbohydrate moieties in transferrin.", BIOCHEMICAL SOCIETY TRANSACTIONS, vol. 26, no. 1, February 1998 (1998-02-01), 663rd Meeting of the Biochemical Society;Galway, Ireland; September 3-5, 1997, pages S48, XP008022933, ISSN: 0300-5127
  • [T] ALTHAUS H ET AL: "Development and evaluation of a new carbohydrate-deficient transferrin (CDT)-specific monoclonal antibody.", CLINICAL CHEMISTRY, vol. 49, no. S6, 20 June 2003 (2003-06-20), 55th Annual Meeting of the AACC;Philadelphia, PA, USA; July 20-24, 2003, pages A113, XP008022934, ISSN: 0009-9147

Citation (examination)

  • DELANGHE ET AL., CLINICAL CHEMISTRY, vol. 53, no. 6, 2007, pages 1115 - 1121
  • VAN HAERINGEN ET AL, PROTEINS: STRUCTURE, FUNCTION AND GENETICS, vol. 23, 1995, pages 233 - 240

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

DOCDB simple family (publication)

EP 1378521 A1 20040107; DE 10230550 A1 20040115; DK 2077280 T3 20150824; EP 2077280 A2 20090708; EP 2077280 A3 20100324; EP 2077280 B1 20150624; ES 2542699 T3 20150810

DOCDB simple family (application)

EP 03011334 A 20030519; DE 10230550 A 20020705; DK 09005276 T 20030519; EP 09005276 A 20030519; ES 09005276 T 20030519