EP 1379495 A2 20040114 - LIGANDS OF THE ALPHA-V-BETA 6 INTEGRIN
Title (en)
LIGANDS OF THE ALPHA-V-BETA 6 INTEGRIN
Title (de)
LIGANDEN DES INTEGRINS AVSS6
Title (fr)
LIGANDS DE L'INTEGRINE ALPHA-V-BETA 6
Publication
Application
Priority
- DE 10118550 A 20010414
- EP 0202728 W 20020313
Abstract (en)
[origin: DE10118550A1] 3-(2-(Acylamino)-ethanoylamino)-3-phenyl-propionic acid derivatives (I), and their stereoisomers, salts and solvates, are new. 3-(2-(Acylamino)-ethanoylamino)-3-phenyl-propionic acid derivatives of formula (I), and their stereoisomers, salts and solvates, are new: X = O or S; Y = NH, O or S; R1 = H, A, Ar, Het, halo, NO2, CN, OH, OA, NH2, NHA, NA2, COOH, CONH2, CONHA or CONA2; R2 = H, A, -(CH2)m-Ar, -(CH2)m-Het, -(CH2)m-cycloalkyl, -(CH2)m-CHA-Ar, -(CH2)m-CHA-Het or -(CH2)m-CHA-cycloalkyl; A = 1-8C alkyl or 2-8C alkenyl or alkadienyl; Het = mono- or binuclear aromatic heterocycle containing 1-4 N, O and/or S heteroatom(s) (optionally substituted by 1 or 2 of halo, A, OH, OA, SA, OCF3, COA, CN, COOA, COOH, CONH2, CONHA, CONA2, NH2, NHA, NA2 or NO2); m = 0 - 2; n = 1 - 4; and Ar = phenyl, naphthyl, anthranyl, fluorenyl, indenyl, anthracenyl or biphenylyl (all optionally substituted by one or more of halo, A, OH, OA, COA, CN, COOA, COOH, CONH2, CONHA, CONA2, CF3, OCF3 or NO2). (N.B. The above definition of Ar is taken from the disclosure, since Ar is not defined in the claims). An Independent claim is also included for the preparation of (I).
IPC 1-7
C07C 275/16; A61K 31/17; A61K 31/27; C07C 275/26; C07C 275/28; C07C 335/12; C07C 335/08; C07C 275/34; C07C 275/30; C07C 271/22; C07C 275/18; C07C 275/20; C07C 275/24
IPC 8 full level
A61K 31/19 (2006.01); A61K 31/197 (2006.01); A61K 31/27 (2006.01); A61P 1/16 (2006.01); A61P 3/10 (2006.01); A61P 3/14 (2006.01); A61P 7/00 (2006.01); A61P 7/02 (2006.01); A61P 9/00 (2006.01); A61P 9/08 (2006.01); A61P 9/10 (2006.01); A61P 11/00 (2006.01); A61P 13/00 (2006.01); A61P 1/04 (2006.01); A61P 13/02 (2006.01); A61P 13/12 (2006.01); A61P 15/00 (2006.01); A61P 15/08 (2006.01); A61P 17/00 (2006.01); A61P 17/02 (2006.01); A61P 17/06 (2006.01); A61P 19/00 (2006.01); A61P 19/02 (2006.01); A61P 19/10 (2006.01); A61P 25/00 (2006.01); A61P 27/00 (2006.01); A61P 27/02 (2006.01); A61P 27/06 (2006.01); A61P 27/10 (2006.01); A61P 29/00 (2006.01); A61P 31/00 (2006.01); A61P 31/04 (2006.01); A61P 31/12 (2006.01); A61P 31/18 (2006.01); A61P 33/00 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); A61P 37/04 (2006.01); A61P 43/00 (2006.01); C07C 269/06 (2006.01); C07C 271/22 (2006.01); C07C 273/18 (2006.01); C07C 275/16 (2006.01); C07C 275/18 (2006.01); C07C 275/20 (2006.01); C07C 275/24 (2006.01); C07C 275/26 (2006.01); C07C 275/28 (2006.01); C07C 275/30 (2006.01); C07C 275/34 (2006.01); C07C 275/42 (2006.01); C07C 335/08 (2006.01); C07C 335/12 (2006.01); C07K 5/023 (2006.01)
CPC (source: EP KR US)
A61P 1/04 (2018.01 - EP); A61P 1/16 (2018.01 - EP); A61P 3/10 (2018.01 - EP); A61P 3/14 (2018.01 - EP); A61P 7/00 (2018.01 - EP); A61P 7/02 (2018.01 - EP); A61P 9/00 (2018.01 - EP); A61P 9/08 (2018.01 - EP); A61P 9/10 (2018.01 - EP); A61P 11/00 (2018.01 - EP); A61P 13/00 (2018.01 - EP); A61P 13/02 (2018.01 - EP); A61P 13/12 (2018.01 - EP); A61P 15/00 (2018.01 - EP); A61P 15/08 (2018.01 - EP); A61P 17/00 (2018.01 - EP); A61P 17/02 (2018.01 - EP); A61P 17/06 (2018.01 - EP); A61P 19/00 (2018.01 - EP); A61P 19/02 (2018.01 - EP); A61P 19/10 (2018.01 - EP); A61P 25/00 (2018.01 - EP); A61P 27/00 (2018.01 - EP); A61P 27/02 (2018.01 - EP); A61P 27/06 (2018.01 - EP); A61P 27/10 (2018.01 - EP); A61P 29/00 (2018.01 - EP); A61P 31/00 (2018.01 - EP); A61P 31/04 (2018.01 - EP); A61P 31/12 (2018.01 - EP); A61P 31/18 (2018.01 - EP); A61P 33/00 (2018.01 - EP); A61P 35/00 (2018.01 - EP); A61P 35/02 (2018.01 - EP); A61P 37/04 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07C 271/22 (2013.01 - EP US); C07C 275/16 (2013.01 - EP KR US); C07C 275/18 (2013.01 - EP US); C07C 275/20 (2013.01 - EP US); C07C 275/24 (2013.01 - EP US); C07C 275/26 (2013.01 - EP US); C07C 275/28 (2013.01 - EP US); C07C 275/30 (2013.01 - EP US); C07C 275/34 (2013.01 - EP US); C07C 335/08 (2013.01 - EP US); C07C 335/12 (2013.01 - EP US); C07B 2200/07 (2013.01 - EP US); C07C 2601/14 (2017.05 - EP US); C07C 2603/18 (2017.05 - EP US)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
US 2004142877 A1 20040722; BR 0208885 A 20040629; CA 2444247 A1 20021024; CN 1501827 A 20040602; CZ 20033000 A3 20040218; DE 10118550 A1 20021017; EP 1379495 A2 20040114; HU P0303804 A2 20040329; HU P0303804 A3 20050928; JP 2004528325 A 20040916; KR 20030090739 A 20031128; MX PA03009318 A 20040212; PL 363328 A1 20041115; RU 2003130639 A 20050410; SK 13732003 A3 20040203; WO 02083627 A2 20021024; WO 02083627 A3 20031009; ZA 200308857 B 20040913
DOCDB simple family (application)
US 47480203 A 20031014; BR 0208885 A 20020313; CA 2444247 A 20020313; CN 02808172 A 20020313; CZ 20033000 A 20020313; DE 10118550 A 20010414; EP 0202728 W 20020313; EP 02747260 A 20020313; HU P0303804 A 20020313; JP 2002581384 A 20020313; KR 20037013447 A 20031013; MX PA03009318 A 20020313; PL 36332802 A 20020313; RU 2003130639 A 20020313; SK 13732003 A 20020313; ZA 200308857 A 20031113