EP 1386274 A2 20040204 - PHARMACOKINETIC TOOL AND METHOD FOR PREDICTING METABOLISM OF A COMPOUND IN A MAMMAL
Title (en)
PHARMACOKINETIC TOOL AND METHOD FOR PREDICTING METABOLISM OF A COMPOUND IN A MAMMAL
Title (de)
PHARMAKOKINETISCHES WERKZEUG UND VERFAHREN ZUR STOFFWECHSELSVORHERSAGE EINER VERBINDUNG IN EINEM TIER
Title (fr)
INSTRUMENT PHARMACOCINETIQUE ET METHODE DESTINEE A PREVOIR LE METABOLISME D'UN COMPOSE CHEZ UN MAMMIFERE
Publication
Application
Priority
- US 0123867 W 20010730
- US 22154800 P 20000728
- US 24410600 P 20001027
- US 26743601 P 20010209
- US 28879301 P 20010507
Abstract (en)
[origin: WO0210746A2] A system for simulating metabolism of a compound in a mammal is disclosed that includes a metabolism simulation model of a mammalian liver. This model has equations which when executed on a computer, calculate the rate of metabolism of the compound in the cells of the mammalian liver and a rate of transport of the compound into the cells, wherein the simulation model determines an amount of the metabolism product. The rate of metabolism may be a rate of depletion of the compound. The metabolism product may be an amount of the compound remaining after the compound's first passage through the mammalian liver (This is not necessarily limited to first pass, nor would it need to be limited to the liver. Intestinal metabolism could also be modeled). The rate of metabolism may alternatively be a rate of accumulation of a metabolite of the compound.
IPC 1-7
IPC 8 full level
G01N 33/15 (2006.01); C12Q 1/02 (2006.01); G06F 19/00 (2011.01)
CPC (source: EP)
G16C 20/30 (2019.01); G16H 10/40 (2017.12); G16H 50/50 (2017.12)
Citation (search report)
See references of WO 0210746A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0210746 A2 20020207; WO 0210746 A3 20031106; AU 7807501 A 20020213; CA 2416810 A1 20020207; EP 1386274 A2 20040204; JP 2004514879 A 20040520
DOCDB simple family (application)
US 0123867 W 20010730; AU 7807501 A 20010730; CA 2416810 A 20010730; EP 01956037 A 20010730; JP 2002516622 A 20010730