Global Patent Index - EP 1388344 A1

EP 1388344 A1 20040211 - Composition comprising Salvia Miltiorrhiza, Ginseng, Borneol for treating heart disease, and cerebrovascular diseases

Title (en)

Composition comprising Salvia Miltiorrhiza, Ginseng, Borneol for treating heart disease, and cerebrovascular diseases

Title (de)

Zusammensetsung enthaltend Salvia Miltiorrhiza, Ginseng, Borneol zur Behandlung von zerebrovaskulären und Herzkrankheiten

Title (fr)

Composition comprenant Salvia Miltiorrhiza, Ginseng, Borneol pour le traitement des maladies cardiaques et cerebrovasculaires

Publication

EP 1388344 A1 20040211 (EN)

Application

EP 03017260 A 20030730

Priority

US 21054802 A 20020731

Abstract (en)

This invention also provides a composition comprising herb extracts from raw herbs of 80.0-97.0% Radix Salviae Miltorrhizae, 1.0-19.0% Panax Notoginseng and 0.1-1.0 Borneol. This invention provides a preparation method comprising steps of: (1) obtaining an appropriate amount of smashed Radix Salviae Miltorrhizae and Panax Notoginseng; (2) extracting the obtained Radix Salviae Miltorrhizae, and Panax Notoginseng in hot aqueous reflux; (3) filtering and combining the extracts to form a combined extract; (4) concentrating the combined extract from step (3) to an appropriate ratio of the volume of the concentrated extract to the weight of the inputted herbal materials to form a concentrated extract; (5) precipitation by organic solvent to form a precipitate; (6) concentrating the supernatant liquid of precipitate resulting from step (5) to form a plaster; (7) mixing the plaster from step (6) with an appropriate amount of Borneol, thereby producing the composition comprising extracts of Radix Salviae Miltorrhizae, Panax Notoginseng and Borneol for heart disease. Finally, this invention provides various uses of said compositions.

IPC 1-7

A61K 35/78

IPC 8 full level

A61K 9/10 (2006.01); A61K 9/16 (2006.01); A61K 9/20 (2006.01); A61K 9/48 (2006.01); A61K 9/50 (2006.01); A61K 31/045 (2006.01); A61K 36/185 (2006.01); A61K 36/25 (2006.01); A61K 36/258 (2006.01); A61K 36/53 (2006.01); A61K 36/537 (2006.01); A61K 36/54 (2006.01); A61K 47/26 (2006.01); A61K 47/34 (2006.01); A61K 47/36 (2006.01); A61P 1/04 (2006.01); A61P 1/16 (2006.01); A61P 1/18 (2006.01); A61P 3/06 (2006.01); A61P 3/10 (2006.01); A61P 7/02 (2006.01); A61P 9/00 (2006.01); A61P 9/06 (2006.01); A61P 9/10 (2006.01); A61P 9/12 (2006.01); A61P 11/00 (2006.01); A61P 13/12 (2006.01); A61P 19/00 (2006.01); A61P 19/02 (2006.01); A61P 25/00 (2006.01); A61P 25/06 (2006.01); A61P 25/28 (2006.01); A61P 27/02 (2006.01); A61P 31/12 (2006.01); A61P 37/04 (2006.01); A61P 39/00 (2006.01); A61P 39/06 (2006.01); A61P 43/00 (2006.01)

CPC (source: EP KR US)

A61K 31/045 (2013.01 - EP US); A61K 36/185 (2013.01 - EP US); A61K 36/258 (2013.01 - EP US); A61K 36/537 (2013.01 - EP KR US); A61K 36/54 (2013.01 - EP US); A61P 1/04 (2017.12 - EP); A61P 1/16 (2017.12 - EP); A61P 1/18 (2017.12 - EP); A61P 3/06 (2017.12 - EP); A61P 3/10 (2017.12 - EP); A61P 7/00 (2017.12 - EP); A61P 7/02 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 9/04 (2017.12 - EP); A61P 9/06 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 9/12 (2017.12 - EP); A61P 11/00 (2017.12 - EP); A61P 13/12 (2017.12 - EP); A61P 19/00 (2017.12 - EP); A61P 19/02 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/06 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 27/02 (2017.12 - EP); A61P 31/12 (2017.12 - EP); A61P 37/04 (2017.12 - EP); A61P 39/00 (2017.12 - EP); A61P 39/06 (2017.12 - EP); A61P 43/00 (2017.12 - EP)

Citation (applicant)

Citation (search report)

  • [PX] WO 02058625 A2 20020801 - TIANJIN TASLY PHARMACEUTICAL [CN], et al
  • [X] US 5589182 A 19961231 - TASHIRO RENKI [JP], et al
  • [A] LI R ET AL: "Quantitative determination of total tanshinone in salvia miltiorrhiza tablet compound", YIYAO GONGYE - PHARMACEUTICAL INDUSTRY, SHANGHAI, CN, vol. 17, no. 11, 1986, pages 513 - 514, XP002954785, ISSN: 0255-7223
  • [A] NI K ET AL: "Determination of active components of salvia miltiorrhiza and notoginseng in compound salvia miltiorrhiza tablets by TLC-densitometry", YAOWU FENXI ZAZHI - CHINESE JOURNAL OF PHARMACEUTICAL ANALYSIS, ZHONGGUO YAOXUEHUI, BEIJING, CN, vol. 9, no. 2, 1989, pages 74 - 77, XP002954784, ISSN: 0254-1793
  • [A] DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; March 1990 (1990-03-01), LIU Y ET AL: "[Evaluation of radix Salviae Miltiorrhizae and its preparation]", XP002262545, Database accession no. NLM2085402
  • [T] ANONYMOUS, INTERNET ARTICLE, XP002262543, Retrieved from the Internet <URL:http://www.carbotrading.com/Products/Medicine/JZ016.htm> [retrieved on 20031118]
  • [T] ANONYMOUS, INTERNET ARTICLE, XP002262544, Retrieved from the Internet <URL:http://www.craneherb.com/products/product001513> [retrieved on 20031118] & ZHONGGUO ZHONG YAO ZA ZHI = ZHONGGUO ZHONGYAO ZAZHI = CHINA JOURNAL OF CHINESE MATERIA MEDICA. CHINA MAR 1990, vol. 15, no. 3, March 1990 (1990-03-01), pages 159 - 162, 190, ISSN: 1001-5302

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

DOCDB simple family (publication)

US 2003152651 A1 20030814; US 8486464 B2 20130716; AU 2003227336 A1 20040219; AU 2003227336 B2 20041216; AU 2003227336 C1 20060223; AU 2003253217 A1 20040223; AU 2003253217 A8 20040223; BR 0302589 A 20040831; CA 2436469 A1 20040131; CA 2436469 C 20150113; EP 1388344 A1 20040211; EP 1388344 B1 20140312; ES 2469490 T3 20140618; HK 1063284 A1 20041224; JP 2005539006 A 20051222; JP 4657714 B2 20110323; KR 101027230 B1 20110406; KR 20050026071 A 20050314; MX PA03006927 A 20041015; MY 140191 A 20091130; NZ 527311 A 20050429; NZ 527372 A 20050429; RU 2005105931 A 20050910; RU 2328300 C2 20080710; SG 116501 A1 20051128; UA 81124 C2 20071210; WO 2004012651 A2 20040212; WO 2004012651 A3 20040617; ZA 200305860 B 20040526

DOCDB simple family (application)

US 21054802 A 20020731; AU 2003227336 A 20030731; AU 2003253217 A 20030731; BR 0302589 A 20030731; CA 2436469 A 20030731; EP 03017260 A 20030730; ES 03017260 T 20030730; HK 04106012 A 20040811; IB 0303774 W 20030731; JP 2004525710 A 20030731; KR 20057001718 A 20030731; MX PA03006927 A 20030731; MY PI20032901 A 20030731; NZ 52731103 A 20030731; NZ 52737203 A 20030805; RU 2005105931 A 20030731; SG 200304274 A 20030731; UA 2005001790 A 20030731; ZA 200305860 A 20030730