EP 1390012 A4 20091028 - NOVEL METHODS AND COMPOSITIONS FOR DELIVERING MACROMOLECULES TO OR VIA THE RESPIRATORY TRACT
Title (en)
NOVEL METHODS AND COMPOSITIONS FOR DELIVERING MACROMOLECULES TO OR VIA THE RESPIRATORY TRACT
Title (de)
NEUE VERFAHREN UND ZUSAMMENSETZUNGEN ZUR FREISETZUNG VON MAKROMOLEKÜLEN AN DIE ODER ÜBER DIE ATEMWEGE
Title (fr)
NOUVELLES METHODES ET COMPOSITIONS D'ADMINISTRATION DE MACROMOLECULES AUX VOIES RESPIRATOIRES OU VIA CELLES-CI
Publication
Application
Priority
- US 0213145 W 20020426
- US 28689101 P 20010426
Abstract (en)
[origin: WO02087542A1] Methods and compositions for delivering macromolecules to or via the respiratory tract, such that the macromolecules exhibit improved local and/or systemic bioavailability are provided. Such methods utilize lipid-based microstructures formed in combination with at least one bioactive macromolecule, which have a superior ability to rapidly release the bioactive macromolecule(s) thereby resulting in improved local and/or systemic bioavailability of the bioactive macromolecule(s). Such improved bioavailability is believed to be due, in part, to reduction of scavenging by bronchoalveolar macrophages and/or mucociliary clearance. Compositions with improved bioavailability are provided comprising a plurality of lipid-based microstructures formed in combination with at least one bioactive macromolecule, wherein the bioavailability of the bioactive macromolecule is improved by modifying the rate of release of the bioactive macromolecule from the microstructure thereby reducing scavenging by bronchoalveolar macrophages and/or mucociliary clearance.
IPC 1-7
A61K 9/127; A61K 9/12; A61K 9/14; A61K 9/16; A61K 9/50; A61K 9/52
IPC 8 full level
A61K 9/00 (2006.01); A61K 9/12 (2006.01); A61K 9/127 (2006.01); A61K 9/14 (2006.01); A61K 9/16 (2006.01); A61K 9/50 (2006.01); A61K 9/52 (2006.01); A61K 47/10 (2006.01); A61K 47/24 (2006.01); A61K 47/26 (2006.01); A61K 47/34 (2006.01); A61K 47/36 (2006.01); A61K 9/107 (2006.01)
CPC (source: EP)
A61K 9/0075 (2013.01); B82Y 5/00 (2013.01); A61K 9/1075 (2013.01); A61K 9/127 (2013.01); A61K 9/1617 (2013.01)
Citation (search report)
- [X] WO 0000215 A1 20000106 - ALLIANCE PHARMA [US], et al
- [DX] WO 9916421 A1 19990408 - ALLIANCE PHARMA [US], et al
- [DX] WO 9916422 A1 19990408 - ALLIANCE PHARMA [US], et al
- [X] WO 9831346 A1 19980723 - MASSACHUSETTS INST TECHNOLOGY [US], et al
- [PX] WO 0185136 A2 20011115 - ALLIANCE PHARMA [US]
- [PX] WO 0185137 A2 20011115 - ALLIANCE PHARMA [US], et al
- [X] WO 9619197 A1 19960627 - ASTRA AB [SE], et al
- [X] DELLAMARY L A ET AL: "HOLLOW POROUS PARTICLES IN METERED DOSE INHALERS", PHARMACEUTICAL RESEARCH, KLUWER ACADEMIC PUBLISHERS, NEW YORK, NY, US, vol. 17, no. 2, 1 February 2000 (2000-02-01), pages 168 - 174, XP009034216, ISSN: 0724-8741
- See references of WO 02087542A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated extension state (EPC)
AL LT LV MK RO SI
DOCDB simple family (publication)
WO 02087542 A1 20021107; EP 1390012 A1 20040225; EP 1390012 A4 20091028; JP 2004528339 A 20040916
DOCDB simple family (application)
US 0213145 W 20020426; EP 02728994 A 20020426; JP 2002584888 A 20020426