EP 1390357 A2 20040225 - ANTI-THROMBOTIC COMPOUNDS, PRODUCTION AND USE THEREOF AS MEDICAMENTS
Title (en)
ANTI-THROMBOTIC COMPOUNDS, PRODUCTION AND USE THEREOF AS MEDICAMENTS
Title (de)
ANTITHROMBOTISCHE VERBINDUNGEN, DEREN HERSTELLUNG UND DEREN VERWENDUNG ALS ARZNEIMITTEL
Title (fr)
COMPOSES ANTITHROMBOTIQUES, LEUR PREPARATION ET LEUR UTILISATION COMME PRODUITS PHARMACEUTIQUES
Publication
Application
Priority
- DE 10104597 A 20010202
- DE 10135435 A 20010726
- EP 0200823 W 20020126
Abstract (en)
[origin: WO02062778A2] The invention relates to anti-thrombotic compounds of general formula (I), where R1 to R4, Ar, A, m and n are as defined in claim 1, the tautomers, stereoisomers, mixtures, pro-drugs and salts thereof which have worthwhile properties. Compounds of the above general formula (I), in which Ar = a phenyl or naphthyl group substituted with the groups R5, R6 and R7 and R5 = a CN group, represent worthwhile intermediate products in the synthesis of the corresponding compounds of general formula (I), in which R5 = an amidino group substituted with one or two C1-3 alkyl groups. The compounds of the above general formula (I), with the exception of those compounds in which Ar = a phenyl or naphthyl group substituted with the groups R5, R6 and R7 and R5 = a CN group, have worthwhile pharmacological properties, in particular an anti-thrombotic effect and a factor Xa-inhibiting effect.
IPC 1-7
IPC 8 full level
C07D 295/18 (2006.01); A61K 31/167 (2006.01); A61K 31/222 (2006.01); A61K 31/40 (2006.01); A61P 7/02 (2006.01); A61P 9/10 (2006.01); A61P 11/00 (2006.01); A61P 17/02 (2006.01); A61P 19/02 (2006.01); C07C 237/38 (2006.01); C07C 237/42 (2006.01); C07C 257/18 (2006.01); C07D 207/18 (2006.01); C07D 295/192 (2006.01)
CPC (source: EP)
A61P 7/02 (2017.12); A61P 9/10 (2017.12); A61P 11/00 (2017.12); A61P 17/02 (2017.12); A61P 19/02 (2017.12); C07C 257/18 (2013.01); C07D 295/192 (2013.01)
Citation (search report)
See references of WO 02062778A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 02062778 A2 20020815; WO 02062778 A3 20031211; CA 2435492 A1 20020815; EP 1390357 A2 20040225; JP 2004522759 A 20040729; MX PA03006648 A 20031015
DOCDB simple family (application)
EP 0200823 W 20020126; CA 2435492 A 20020126; EP 02714118 A 20020126; JP 2002563132 A 20020126; MX PA03006648 A 20020126