EP 1392340 A2 20040303 - CYTOTOXIC PEPTIDES AND PEPTIDOMIMETICS BASED THEREON, AND METHODS FOR USE THEREOF
Title (en)
CYTOTOXIC PEPTIDES AND PEPTIDOMIMETICS BASED THEREON, AND METHODS FOR USE THEREOF
Title (de)
ZYTOTOXISCHE PEPTIDE UND DARAUF BASIERENDE PEPTIDOMIMETIKA UND VERFAHREN ZUR VERWENDUNG DAVON
Title (fr)
PEPTIDES CYTOTOXIQUES, PEPTIDOMIMETIQUES BASES SUR CES PEPTIDES, ET METHODES D'UTILISATION
Publication
Application
Priority
- US 0209649 W 20020329
- US 28051501 P 20010330
- US 28105001 P 20010402
- US 28061501 P 20010330
Abstract (en)
[origin: WO02092788A2] In accordance with the present invention, it has been discovered that the beta -amyloid precursor protein (APP), and two APP-like proteins (APLP1 and APLP2) are proteolytically cleaved by caspases in the C terminus to generate an approximately 31 amino acid peptide. It has been further discovered that the resultant C-terminal peptide is a potent inducer of apoptosis. Both caspase-cleaved APP and activated caspase-9 is present in brains of Alzheimer's disease patients but not in control brains. These findings indicate that caspase cleavage of APP and APP-like proteins leads to the generation of apoptotic peptides, which may contribute to the neuronal death associated with Alzheimer's disease. Accordingly, there are provided compositions and methods for modulating apoptosis.
IPC 1-7
IPC 8 full level
A61K 31/7088 (2006.01); A61K 38/00 (2006.01); A61K 38/04 (2006.01); A61K 38/17 (2006.01); A61K 39/395 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 25/28 (2006.01); C07K 14/00 (2006.01); C07K 14/47 (2006.01); C07K 14/705 (2006.01); C07K 16/00 (2006.01); C07K 17/00 (2006.01); C12Q 1/02 (2006.01); G01N 33/53 (2006.01)
CPC (source: EP)
A61P 25/28 (2017.12); C07K 14/4711 (2013.01); C07K 14/4747 (2013.01); A61K 38/00 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 02092788 A2 20021121; WO 02092788 A3 20031218; WO 02092788 A9 20040506; AU 2009227824 A1 20091105; CA 2443160 A1 20021121; EP 1392340 A2 20040303; EP 1392340 A4 20060426
DOCDB simple family (application)
US 0209649 W 20020329; AU 2009227824 A 20091016; CA 2443160 A 20020329; EP 02731181 A 20020329