Global Patent Index - EP 1392340 A4

EP 1392340 A4 20060426 - CYTOTOXIC PEPTIDES AND PEPTIDOMIMETICS BASED THEREON, AND METHODS FOR USE THEREOF

Title (en)

CYTOTOXIC PEPTIDES AND PEPTIDOMIMETICS BASED THEREON, AND METHODS FOR USE THEREOF

Title (de)

ZYTOTOXISCHE PEPTIDE UND DARAUF BASIERENDE PEPTIDOMIMETIKA UND VERFAHREN ZUR VERWENDUNG DAVON

Title (fr)

PEPTIDES CYTOTOXIQUES, PEPTIDOMIMETIQUES BASES SUR CES PEPTIDES, ET METHODES D'UTILISATION

Publication

EP 1392340 A4 20060426 (EN)

Application

EP 02731181 A 20020329

Priority

  • US 0209649 W 20020329
  • US 28051501 P 20010330
  • US 28105001 P 20010402
  • US 28061501 P 20010330

Abstract (en)

[origin: WO02092788A2] In accordance with the present invention, it has been discovered that the beta -amyloid precursor protein (APP), and two APP-like proteins (APLP1 and APLP2) are proteolytically cleaved by caspases in the C terminus to generate an approximately 31 amino acid peptide. It has been further discovered that the resultant C-terminal peptide is a potent inducer of apoptosis. Both caspase-cleaved APP and activated caspase-9 is present in brains of Alzheimer's disease patients but not in control brains. These findings indicate that caspase cleavage of APP and APP-like proteins leads to the generation of apoptotic peptides, which may contribute to the neuronal death associated with Alzheimer's disease. Accordingly, there are provided compositions and methods for modulating apoptosis.

IPC 1-7

A61K 38/00; C07K 14/00; C07K 16/00; C07K 17/00

IPC 8 full level

A61K 31/7088 (2006.01); A61K 38/00 (2006.01); A61K 38/04 (2006.01); A61K 38/17 (2006.01); A61K 39/395 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 25/28 (2006.01); C07K 14/00 (2006.01); C07K 14/47 (2006.01); C07K 14/705 (2006.01); C07K 16/00 (2006.01); C07K 17/00 (2006.01); C12Q 1/02 (2006.01); G01N 33/53 (2006.01)

CPC (source: EP)

A61P 25/28 (2017.12); C07K 14/4711 (2013.01); C07K 14/4747 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

  • [X] WO 9815828 A1 19980416 - SCIOS INC [US], et al
  • [XY] LU D C ET AL: "A SECOND CYTOTOXIC PROTEOLYTIC PEPTIDE DERIVED FROM AMYLOID BETA-PROTEIN PRECURSOR", NATURE MEDICINE, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 6, no. 4, April 2000 (2000-04-01), pages 397 - 404, XP000917557, ISSN: 1078-8956
  • [DXY] LEBLANC ANDREA ET AL: "Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 33, 13 August 1999 (1999-08-13), pages 23426 - 23436, XP002353860, ISSN: 0021-9258
  • [XY] PINNIX I ET AL: "A novel gamma -secretase assay based on detection of the putative C-terminal fragment-gamma of amyloid beta protein precursor", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 276, no. 1, 5 January 2001 (2001-01-05), pages 481 - 487, XP002217635, ISSN: 0021-9258
  • [X] DOVEY H F ET AL: "FUNCTIONAL GAMMA-SECRETASE INHIBITORS REDUCE BETA-AMYLOID PEPTIDE LEVELS IN BRAIN", JOURNAL OF NEUROCHEMISTRY, NEW YORK, NY, US, vol. 76, no. 1, January 2001 (2001-01-01), pages 173 - 181, XP001147446, ISSN: 0022-3042
  • [A] PALIGA K ET AL: "HUMAN AMYLOID PRECURSOR-LIKE PROTEIN 1 CDNA CLONING, ECTOPIC EXPRESSION IN COS-7 CELLS AND IDENTIFICATION OF SOLUBLE FORMS IN THE CEREBROSPINAL FLUID", EUROPEAN JOURNAL OF BIOCHEMISTRY, BERLIN, DE, vol. 250, no. 2, 1 December 1997 (1997-12-01), pages 354 - 363, XP000870182, ISSN: 0014-2956
  • [A] SPRECHER CINDY A ET AL: "Molecular cloning of the cDNA for a human amyloid precursor protein homolog: Evidence for a multigene family", BIOCHEMISTRY, vol. 32, no. 17, 1993, pages 4481 - 4486, XP002368588, ISSN: 0006-2960
  • [PX] DUMANCHIN-NJOCK CECILE ET AL: "The caspase-derived C-terminal fragment of betaAPP induces caspase-independent toxicity and triggers selective increase of Abeta42 in mammalian cells", JOURNAL OF NEUROCHEMISTRY, vol. 78, no. 5, September 2001 (2001-09-01), pages 1153 - 1161, XP002353861, ISSN: 0022-3042
  • [PX] COWAN CATHERINE M ET AL: "Caspases 3 and 9 send a pro-apoptotic signal from synapse to cell body in olfactory receptor neurons", JOURNAL OF NEUROSCIENCE, vol. 21, no. 18, 15 September 2001 (2001-09-15), pages 7099 - 7109, XP002368589, ISSN: 0270-6474
  • [T] GALVAN VERONICA ET AL: "Caspase cleavage of members of the amyloid precursor family of proteins", JOURNAL OF NEUROCHEMISTRY, vol. 82, no. 2, July 2002 (2002-07-01), pages 283 - 294, XP002368590, ISSN: 0022-3042
  • See references of WO 02092788A2

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

WO 02092788 A2 20021121; WO 02092788 A3 20031218; WO 02092788 A9 20040506; AU 2009227824 A1 20091105; CA 2443160 A1 20021121; EP 1392340 A2 20040303; EP 1392340 A4 20060426

DOCDB simple family (application)

US 0209649 W 20020329; AU 2009227824 A 20091016; CA 2443160 A 20020329; EP 02731181 A 20020329