EP 1392654 A1 20040303 - INTEGRIN ANTAGONISTS
Title (en)
INTEGRIN ANTAGONISTS
Title (de)
INTEGRINANTAGONISTEN
Title (fr)
ANTAGONISTES D'INTEGRINE
Publication
Application
Priority
- DE 10127041 A 20010602
- EP 0204856 W 20020503
Abstract (en)
[origin: DE10127041A1] N-Substituted glycine N-(1-biphenyl-4-yl-2-(tetrazolyl or sulfonylaminocarbonyl)-ethyl)-amides (I) are new. Biphenyl derivatives of formula (I) and their stereoisomers, salts and solvates are new. A = NH2, C(=NH)NH2, NHC(=NH)NH2, A'C(=NH)NH2, Het1 or -NH-Het1 (where the primary amino groups are optionally conventionally protected); B' = tetrazolyl or RSO2NHCO-; R = H, A', 6-14C cycloalkyl, 6-10C aryl or 7-14C aralkyl (optionally substituted by one or more R3 and optionally having the alkyl chain interrupted by O); R1, R'1, R''1, R2, R'2, R''2 = H, halo, NO2, NH2, NHR, N(R)2, OH, OR, COR, SO3R, SO2R or SR; R3 = halo, NO2, CF3, OH, CN, OCF3, SCF3, OMe or OEt; Het1 = mono- or bicyclic heterocycle containing 1-4 N, optionally substituted by 1 or 2 of A', NHA', N(A')2 and/or NH2; A' = 1-8C alkyl; X = direct bond, O, NH or CH2; n = 2-4. An Independent claim is also included for the preparation of (I).
IPC 1-7
C07D 213/74; C07D 401/12; A61K 31/41; A61K 31/435; A61P 9/00; A61P 35/00
IPC 8 full level
A61P 9/00 (2006.01); A61P 35/00 (2006.01); C07D 213/74 (2006.01); C07D 401/12 (2006.01)
CPC (source: EP US)
A61P 9/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP); C07D 213/74 (2013.01 - EP US); C07D 401/12 (2013.01 - EP US)
Citation (search report)
See references of WO 02098858A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
DE 10127041 A1 20021205; EP 1392654 A1 20040303; US 2004157902 A1 20040812; WO 02098858 A1 20021212
DOCDB simple family (application)
DE 10127041 A 20010602; EP 0204856 W 20020503; EP 02742933 A 20020503; US 47906003 A 20031126