EP 1392657 A4 20040310 - PROTEASE INHIBITORS
Title (en)
PROTEASE INHIBITORS
Title (de)
PROTEASEINHIBITOREN
Title (fr)
INHIBITEURS DE LA PROTEASE
Publication
Application
Priority
- US 0151647 W 20011119
- US 25250800 P 20001122
Abstract (en)
[origin: WO03053331A2] The present invention provides C3-C6 1-amino-1-acyl cycloalkane-substituted 4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, novel intermediates of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting said bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.
IPC 1-7
IPC 8 full level
A61K 31/55 (2006.01); A61P 1/02 (2006.01); A61P 19/00 (2006.01); A61P 19/02 (2006.01); C07D 405/12 (2006.01); A61P 19/10 (2006.01); A61P 29/00 (2006.01); A61P 43/00 (2006.01); C07D 405/14 (2006.01); C07D 409/04 (2006.01); C07D 495/04 (2006.01)
CPC (source: EP KR)
A61P 1/02 (2018.01 - EP); A61P 19/00 (2018.01 - EP); A61P 19/02 (2018.01 - EP); A61P 19/10 (2018.01 - EP); A61P 29/00 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07D 405/14 (2013.01 - EP KR); C07D 409/04 (2013.01 - EP)
Citation (search report)
- [E] WO 0195911 A1 20011220 - SMITHKLINE BEECHAM CORP [US], et al
- [A] WO 0038687 A1 20000706 - SMITHKLINE BEECHAM CORP [US], et al
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 03053331 A2 20030703; WO 03053331 A3 20031113; AR 034278 A1 20040218; AU 2001298052 A1 20030709; BR 0115473 A 20040928; CA 2436850 A1 20030703; CN 1635903 A 20050706; CZ 20031403 A3 20031015; EP 1392657 A2 20040303; EP 1392657 A4 20040310; HU P0301964 A2 20070228; HU P0301964 A3 20070928; IL 155997 A0 20031223; JP 2005513083 A 20050512; KR 20040004445 A 20040113; MX PA03004542 A 20030910; NO 20032328 D0 20030522; NO 20032328 L 20030702; PL 366232 A1 20050124; UY 27032 A1 20020731; ZA 200303848 B 20040628
DOCDB simple family (application)
US 0151647 W 20011119; AR P010105409 A 20011120; AU 2001298052 A 20011119; BR 0115473 A 20011119; CA 2436850 A 20011119; CN 01822053 A 20011119; CZ 20031403 A 20011119; EP 01275089 A 20011119; HU P0301964 A 20011119; IL 15599701 A 20011119; JP 2003554091 A 20011119; KR 20037006807 A 20030520; MX PA03004542 A 20011119; NO 20032328 A 20030522; PL 36623201 A 20011119; UY 27032 A 20011121; ZA 200303848 A 20030516