EP 1392683 B1 20091202 - SUBSTITUTED 4H-CHROMENES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THEIR USE AS ANTICANCER AGENTS
Title (en)
SUBSTITUTED 4H-CHROMENES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THEIR USE AS ANTICANCER AGENTS
Title (de)
SUBSTITUIERTE 4H-CHROMENE UND ANALOGA ALS AKTIVATOREN VON CASPASEN UND INDUKTOREN VON APOPTOSE, UND DEREN VERWENDUNG ALS ANTIKREBSMITTEL
Title (fr)
4H-CHROMÈNES SUBSTITUÉS ET ANALOGUES EN TANT QU'ACTIVATEURS DE CASPASES ET INDUCTEURS D'APOPTOSE, ET LEUR UTILISATION COMME AGENTS ANTICANCÉREUX
Publication
Application
Priority
- US 0215399 W 20020516
- US 29099701 P 20010516
Abstract (en)
[origin: WO02092594A1] The present invention is directed to substituted 4<i>H</i>-chromenes and analogs thereof, represented by Formula (UI) wherein R1-R5, A, Y and Z are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which controlled growth and spread of abnormal cells occurs.
IPC 8 full level
C07D 409/00 (2006.01); A61K 31/35 (2006.01); A61K 31/352 (2006.01); A61K 31/38 (2006.01); A61K 31/382 (2006.01); A61K 31/40 (2006.01); A61K 31/4025 (2006.01); A61K 31/407 (2006.01); A61K 31/415 (2006.01); A61K 31/4188 (2006.01); A61K 31/44 (2006.01); A61K 31/453 (2006.01); A61K 31/47 (2006.01); A61K 31/495 (2006.01); A61K 31/496 (2006.01); A61K 31/497 (2006.01); A61K 31/4985 (2006.01); A61K 31/50 (2006.01); A61K 31/505 (2006.01); A61K 31/506 (2006.01); A61K 31/535 (2006.01); A61K 31/5377 (2006.01); A61K 33/24 (2006.01); A61K 45/06 (2006.01); A61P 1/00 (2006.01); A61P 17/00 (2006.01); A61P 17/06 (2006.01); A61P 19/02 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); A61P 37/02 (2006.01); A61P 43/00 (2006.01); C07D 207/00 (2006.01); C07D 209/02 (2006.01); C07D 215/54 (2006.01); C07D 231/00 (2006.01); C07D 233/02 (2006.01); C07D 241/36 (2006.01); C07D 265/30 (2006.01); C07D 311/04 (2006.01); C07D 311/58 (2006.01); C07D 311/64 (2006.01); C07D 335/06 (2006.01); C07D 401/00 (2006.01); C07D 403/00 (2006.01); C07D 405/00 (2006.01); C07D 405/04 (2006.01); C07D 491/04 (2006.01); C07D 491/052 (2006.01); C07D 493/04 (2006.01); C07D 495/04 (2006.01)
CPC (source: EP US)
A61K 31/35 (2013.01 - EP US); A61K 31/353 (2013.01 - EP US); A61K 31/38 (2013.01 - EP US); A61K 31/40 (2013.01 - EP US); A61K 31/407 (2013.01 - EP US); A61K 31/415 (2013.01 - EP US); A61K 31/44 (2013.01 - EP US); A61K 31/47 (2013.01 - EP US); A61K 31/495 (2013.01 - EP US); A61K 31/497 (2013.01 - EP US); A61K 31/50 (2013.01 - EP US); A61K 31/505 (2013.01 - EP US); A61K 31/535 (2013.01 - EP US); A61K 45/06 (2013.01 - EP US); A61P 1/00 (2017.12 - EP); A61P 17/00 (2017.12 - EP); A61P 17/06 (2017.12 - EP); A61P 19/02 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 35/02 (2017.12 - EP); A61P 37/02 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 215/54 (2013.01 - EP US); C07D 311/58 (2013.01 - EP US); C07D 311/64 (2013.01 - EP US); C07D 335/06 (2013.01 - EP US); C07D 405/04 (2013.01 - EP US); C07D 491/04 (2013.01 - EP US); C07D 493/04 (2013.01 - EP US); C07D 495/04 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated extension state (EPC)
AL LT LV MK RO SI
DOCDB simple family (publication)
WO 02092594 A1 20021121; WO 02092594 A8 20040624; AT E450531 T1 20091215; AU 2009200374 A1 20090326; AU 2009200374 B2 20111027; CA 2447010 A1 20021121; CA 2447010 C 20110802; CN 100564377 C 20091202; CN 1516700 A 20040728; DE 60234589 D1 20100114; EP 1392683 A1 20040303; EP 1392683 A4 20051026; EP 1392683 B1 20091202; ES 2337558 T3 20100427; JP 2004530692 A 20041007; JP 4593880 B2 20101208; US 2003065018 A1 20030403; US 2006035925 A1 20060216; US 7053117 B2 20060530
DOCDB simple family (application)
US 0215399 W 20020516; AT 02741704 T 20020516; AU 2009200374 A 20090203; CA 2447010 A 20020516; CN 02812067 A 20020516; DE 60234589 T 20020516; EP 02741704 A 20020516; ES 02741704 T 20020516; JP 2002589478 A 20020516; US 14613802 A 20020516; US 15058605 A 20050613