EP 1395276 A1 20040310 - STRUCTURALLY MODIFIED PEPTIDES AND USES THEREOF
Title (en)
STRUCTURALLY MODIFIED PEPTIDES AND USES THEREOF
Title (de)
STRUKTUR-MODIFIZIERTE PEPTIDE UND IHRE VERWENDUNGEN
Title (fr)
PEPTIDES STRUCTURELLEMENT MODIFIES ET LEURS UTILISATIONS
Publication
Application
Priority
- US 0215217 W 20020514
- US 29064601 P 20010515
Abstract (en)
[origin: WO02092120A1] This invention relates to modified peptides that bind to an HLA molecule, particularly an HLA-A*0201 molecule wherein the modified peptides have a binding efficiency and immunogenicity similar to that of the parental non-modified peptide. This invention relates particularly to modified analogs of the tumor associated antigen Melan-A26-35A27L that have at least, one or more modified amino acid at positions lor 2 or (b ) one or more modified amino acid at positions 8, 9 or 10. The isolated modified peptides have a half-life in human serum of at least about 12 hours. Also disclosed are methods of using 10 such modified peptides. The invention also relates to methods for using the modified peptides of this invention.
IPC 1-7
IPC 8 full level
A61K 38/17 (2006.01); C07K 14/47 (2006.01)
CPC (source: EP)
A61K 38/1709 (2013.01); C07K 14/4748 (2013.01)
DOCDB simple family (publication)
WO 02092120 A1 20021121; EP 1395276 A1 20040310; EP 1395276 A4 20041229
DOCDB simple family (application)
US 0215217 W 20020514; EP 02731790 A 20020514