Global Patent Index - EP 1395276 A4

EP 1395276 A4 20041229 - STRUCTURALLY MODIFIED PEPTIDES AND USES THEREOF

Title (en)

STRUCTURALLY MODIFIED PEPTIDES AND USES THEREOF

Title (de)

STRUKTUR-MODIFIZIERTE PEPTIDE UND IHRE VERWENDUNGEN

Title (fr)

PEPTIDES STRUCTURELLEMENT MODIFIES ET LEURS UTILISATIONS

Publication

EP 1395276 A4 20041229 (EN)

Application

EP 02731790 A 20020514

Priority

  • US 0215217 W 20020514
  • US 29064601 P 20010515

Abstract (en)

[origin: WO02092120A1] This invention relates to modified peptides that bind to an HLA molecule, particularly an HLA-A*0201 molecule wherein the modified peptides have a binding efficiency and immunogenicity similar to that of the parental non-modified peptide. This invention relates particularly to modified analogs of the tumor associated antigen Melan-A26-35A27L that have at least, one or more modified amino acid at positions lor 2 or (b ) one or more modified amino acid at positions 8, 9 or 10. The isolated modified peptides have a half-life in human serum of at least about 12 hours. Also disclosed are methods of using 10 such modified peptides. The invention also relates to methods for using the modified peptides of this invention.

IPC 1-7

C07K 14/47; A61K 38/17

IPC 8 full level

A61K 38/17 (2006.01); C07K 14/47 (2006.01)

CPC (source: EP)

A61K 38/1709 (2013.01); C07K 14/4748 (2013.01)

Citation (search report)

  • [A] WO 9833511 A1 19980806 - LUDWIG INST CANCER RES [US], et al
  • [PX] WO 0170772 A2 20010927 - PF MEDICAMENT [FR], et al
  • [DY] VALMORI D ET AL: "ENHANCED GENERATION OF SPECIFIC TUMOR-REACTIVE CTL IN VITRO BY SELECTED MELAN-A/MART-1 IMMUNODOMINANT PEPTIDE ANALOGUES", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 160, no. 4, 1998, pages 1750 - 1758, XP000887160, ISSN: 0022-1767
  • [Y] BRINCKERHOFF L H ET AL: "Terminal modifications inhibit proteolytic degradation of an immunogenic MART-1(27-35) peptide: implications for peptide vaccines.", INTERNATIONAL JOURNAL OF CANCER. JOURNAL INTERNATIONAL DU CANCER. 29 OCT 1999, vol. 83, no. 3, 29 October 1999 (1999-10-29), pages 326 - 334, XP002303298, ISSN: 0020-7136
  • [A] AYYOUB MAHA ET AL: "Analysis of the degradation mechanisms of MHC class I-presented tumor antigenic peptides by high performance liquid chromatography/electrospray ionization mass spectrometry: Application to the design of peptidase-resistant analogs", RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 12, no. 9, 1998, pages 557 - 564, XP008037828, ISSN: 0951-4198
  • [A] QUESNEL A ET AL: "Synthesis and antigenic properties of reduced peptide bond analogues of an immunodominant epitope of the melanoma MART-1 protein.", JOURNAL OF PEPTIDE SCIENCE : AN OFFICIAL PUBLICATION OF THE EUROPEAN PEPTIDE SOCIETY. MAR 2001, vol. 7, no. 3, March 2001 (2001-03-01), pages 157 - 165, XP008037820, ISSN: 1075-2617
  • [A] GUICHARD G ET AL: "Melanoma peptide MART-1(27-35) analogues with enhanced binding capacity to the human class I histocompatibility molecule HLA-A2 by introduction of a beta-amino acid residue: implications for recognition by tumor-infiltrating lymphocytes.", JOURNAL OF MEDICINAL CHEMISTRY. 5 OCT 2000, vol. 43, no. 20, 5 October 2000 (2000-10-05), pages 3803 - 3808, XP002303299, ISSN: 0022-2623
  • [A] BIANCO A ET AL: "N-Hydroxy-amide analogues of MHC-class I peptide ligands with nanomolar binding affinities.", JOURNAL OF PEPTIDE SCIENCE : AN OFFICIAL PUBLICATION OF THE EUROPEAN PEPTIDE SOCIETY. DEC 1998, vol. 4, no. 8, December 1998 (1998-12-01), pages 471 - 478, XP008037890, ISSN: 1075-2617
  • [PXT] BLANCHET J S ET AL: "A new generation of Melan-A/MART-1 peptides that fulfill both increased immunogenicity and high resistance to biodegradation: implication for molecular anti-melanoma immunotherapy.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 15 NOV 2001, vol. 167, no. 10, 15 November 2001 (2001-11-15), pages 5852 - 5861, XP002303301, ISSN: 0022-1767
  • [PX] BECK A ET AL: "Stability and CTL activity of N-terminal glutamic acid containing peptides.", THE JOURNAL OF PEPTIDE RESEARCH : OFFICIAL JOURNAL OF THE AMERICAN PEPTIDE SOCIETY. JUN 2001, vol. 57, no. 6, June 2001 (2001-06-01), pages 528 - 538, XP002303302, ISSN: 1397-002X
  • See references of WO 02092120A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

WO 02092120 A1 20021121; EP 1395276 A1 20040310; EP 1395276 A4 20041229

DOCDB simple family (application)

US 0215217 W 20020514; EP 02731790 A 20020514