EP 1395281 A4 20050406 - RECOMBINANT MHC MOLECULES USEFUL FOR MANIPULATION OF ANTIGEN-SPECIFIC T-CELLS
Title (en)
RECOMBINANT MHC MOLECULES USEFUL FOR MANIPULATION OF ANTIGEN-SPECIFIC T-CELLS
Title (de)
REKOMBINANTE MHC-MOLEKÜLE ZUR MANIPULATION VON ANTIGEN-SPEZIFISCHEN T-ZELLEN
Title (fr)
MOLECULES MHC RECOMBINEES UTILES POUR LA MANIPULATION DE LYMPHOCYTES T A SPECIFICITE ANTIGENIQUE
Publication
Application
Priority
- US 0213873 W 20020501
- US 84717201 A 20010501
Abstract (en)
[origin: WO02087613A1] Two-domain MHC polypeptides useful for manipulation of antigen-specific T-cells are disclosed. These polypeptides include MHC class II-based molecules that comprise covalently linked beta 1 and alpha 1 domains, and MHC class I-based molecules that comprise covalently linked alpha 1 and alpha 2 domains. These polypeptides may also include covalently linked antigenic determinants, toxic moieties, and/or detectable labels. The disclosed polypeptides can be used to target antigen-specific T-cells, and are useful, among other things, to detect and purify antigen-specific T-celles, to induce or activate T-cells, and to treat conditions mediated by antigen-specific T-cells.
IPC 1-7
IPC 8 full level
A61K 39/00 (2006.01); A61P 37/04 (2006.01); C07K 14/74 (2006.01); C12N 15/09 (2006.01); G01N 33/50 (2006.01); G01N 33/569 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP US)
A61K 39/4611 (2023.05 - EP); A61K 39/4612 (2023.05 - EP); A61K 39/4613 (2023.05 - EP); A61K 39/4621 (2023.05 - EP); A61K 39/4622 (2023.05 - EP); A61K 39/46433 (2023.05 - EP); A61P 37/00 (2018.01 - EP); A61P 37/04 (2018.01 - EP); A61P 37/06 (2018.01 - EP); C07K 14/70539 (2013.01 - EP US); G01N 33/505 (2013.01 - EP US); G01N 33/56972 (2013.01 - EP US); G01N 33/56977 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US); A61K 39/00 (2013.01 - EP US); A61K 2239/31 (2023.05 - EP); C07K 2319/00 (2013.01 - EP US)
Citation (search report)
- [X] WO 9914236 A1 19990325 - BURROWS GREGORY G [US], et al
- [Y] WO 9523814 A1 19950908 - NAT JEWISH CT IMMUN & RESPIRAT [US], et al
- [Y] WO 9909064 A1 19990225 - SINAI SCHOOL MEDICINE [US], et al
- [X] BURROWS G G ET AL: "Two-domain MHC class II molecules form stable complexes with myelin basic protein 69-89 peptide that detect and inhibit rat encephalitogenic T cells and treat experimental autoimmune encephalomyelitis", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 161, 1998, pages 5987 - 5996, XP002216664, ISSN: 0022-1767
- [X] BURROWS G G ET AL: "Regulation of encephalitogenic T cells with recombinant TCR ligands.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 15 JUN 2000, vol. 164, no. 12, 15 June 2000 (2000-06-15), pages 6366 - 6371, XP002317105, ISSN: 0022-1767
- [Y] SMITH K J ET AL: "Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein", JOURNAL OF EXPERIMENTAL MEDICINE, TOKYO, JP, vol. 18, no. 8, 19 October 1998 (1998-10-19), pages 1511 - 1520, XP002228793, ISSN: 0022-1007
- [Y] LI Y ET AL: "Structural basis for the binding of an immunodominant peptide from myelin basic protein in different registers by two HLA-DR2 proteins", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 304, no. 2, 24 November 2000 (2000-11-24), pages 177 - 188, XP004469167, ISSN: 0022-2836
- See also references of WO 02087613A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 02087613 A1 20021107; AU 2002338535 B2 20080103; CA 2446408 A1 20021107; CA 2446408 C 20131029; EP 1395281 A1 20040310; EP 1395281 A4 20050406; US 2003007978 A1 20030109; US 2008267987 A1 20081030; US 2011262479 A1 20111027
DOCDB simple family (application)
US 0213873 W 20020501; AU 2002338535 A 20020501; CA 2446408 A 20020501; EP 02766900 A 20020501; US 1692008 A 20080118; US 201113093545 A 20110425; US 84717201 A 20010501