Global Patent Index - EP 1395301 A1

EP 1395301 A1 20040310 - CROSSLINKABLE MACROMERS

Title (en)

CROSSLINKABLE MACROMERS

Title (de)

VERNETZBARE MACROMERE

Title (fr)

MACROMERES RETICULABLES

Publication

EP 1395301 A1 20040310 (EN)

Application

EP 01942016 A 20010607

Priority

US 0118345 W 20010607

Abstract (en)

[origin: WO02100453A1] A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer system includes two or more polymer-pendent polymerizable groups and one or more initiator groups (e.g., polymer-pendent initiator groups). The polymerizable groups and the initiator group(s), when polymer-pendent, can be pendent on the same or different polymeric backbones. The macromer system provides advantages over the use of polymerizable macromers and separate, low molecular weight initiators, including advantages with respect to such properties as nontoxicity, efficiency, and solubility. A macromer system of the invention can be used as an interface between the tissue site and implant article in a manner sufficient to permit tissue growth through the corsslinked matrix and between the tissue site and implant. In a preferred embodiment, polymers with pendent polymerizable groups, for use in the macromer system, are prepared by reacting a polysaccharide polymer with a reactive moiety in an organic, polar solvent such as formamide.

IPC 1-7

A61L 27/34; A61L 31/10; A61L 24/00

IPC 8 full level

A61L 27/00 (2006.01); A61K 31/155 (2006.01); A61K 38/00 (2006.01); A61L 15/64 (2006.01); A61L 24/00 (2006.01); A61L 26/00 (2006.01); A61L 27/34 (2006.01); A61L 31/10 (2006.01); C08F 299/00 (2006.01)

CPC (source: EP)

A61L 24/0031 (2013.01); A61L 27/34 (2013.01); A61L 31/10 (2013.01)

Citation (search report)

See references of WO 02100453A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

WO 02100453 A1 20021219; CA 2449964 A1 20021219; EP 1395301 A1 20040310; JP 2005508663 A 20050407; MX PA03011263 A 20040226

DOCDB simple family (application)

US 0118345 W 20010607; CA 2449964 A 20010607; EP 01942016 A 20010607; JP 2003503270 A 20010607; MX PA03011263 A 20010607