EP 1395567 A1 20040310 - 4 (PHENYL-PIPERAZINYL-METHYL) BENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PAIN ANXIETY OR GASTROINTESTINAL DISORDERS
Title (en)
4 (PHENYL-PIPERAZINYL-METHYL) BENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PAIN ANXIETY OR GASTROINTESTINAL DISORDERS
Title (de)
4-(PHENYLPIPERAZINYLMETHYL) BENZAMIDDERIVATE UND DEREN VERWENDUNG ZUR BEHANDLUNG VON SCHMERZEN, ANGST ODER GASTROINTESTINALEN STÖRUNGEN
Title (fr)
DERIVES DE 4(PHENYL-PIPERAZINE-METHYLE) BENZAMIDE ET UTILISATION DE CES DERIVES POUR LE TRAITEMENT DE LA DOULEUR, DE L'ANXIETE OU DES TROUBLES GASTRO-INTESTINAUX
Publication
Application
Priority
- SE 0200956 W 20020516
- SE 0101772 A 20010518
- SE 0103820 A 20011115
Abstract (en)
[origin: WO02094794A1] Compounds of general formula I R<1> is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl, triazolyl, thiazolyl, and pyridine N-oxide; R<2> is independently selected from ethyl and isopropyl; R<3> is independently selected from hydrogen and fluoro; R<4> is independently selected from -OH, -NH2 and -NHSO2R<5>; and R<5> is independently selected from hydrogen, -CF3 and C1-C6 alkyl, or salts thereof or separate enantiomers and salts thereof; where each R<1> heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1-C6 alkyl, NO2, CF3, C1-C6 alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as separate enantiomers of the compounds and salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain, anxiety and functional gastrointestinal disorders.
IPC 1-7
C07D 233/94; C07D 295/155; C07D 333/20; A61K 31/495; A61K 31/496; A61P 25/04; A61P 25/22
IPC 8 full level
A61K 31/495 (2006.01); A61K 31/496 (2006.01); A61P 1/04 (2006.01); A61P 25/04 (2006.01); A61P 25/22 (2006.01); A61P 29/00 (2006.01); C07D 233/24 (2006.01); C07D 295/14 (2006.01); C07D 233/64 (2006.01); C07D 233/94 (2006.01); C07D 295/155 (2006.01); C07D 307/52 (2006.01); C07D 307/66 (2006.01); C07D 333/20 (2006.01)
CPC (source: EP KR US)
A61P 1/00 (2018.01 - EP); A61P 1/04 (2018.01 - EP); A61P 19/00 (2018.01 - EP); A61P 19/02 (2018.01 - EP); A61P 25/00 (2018.01 - EP); A61P 25/04 (2018.01 - EP); A61P 25/06 (2018.01 - EP); A61P 25/14 (2018.01 - EP); A61P 25/16 (2018.01 - EP); A61P 25/22 (2018.01 - EP); A61P 25/24 (2018.01 - EP); A61P 25/28 (2018.01 - EP); A61P 25/30 (2018.01 - EP); A61P 25/32 (2018.01 - EP); A61P 25/36 (2018.01 - EP); A61P 29/00 (2018.01 - EP); A61P 37/00 (2018.01 - EP); A61P 37/02 (2018.01 - EP); A61P 37/06 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07D 233/24 (2013.01 - EP US); C07D 295/155 (2013.01 - EP US); C07D 307/52 (2013.01 - EP US); C07D 333/20 (2013.01 - EP US); C07D 401/06 (2013.01 - KR)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated extension state (EPC)
AL LT LV MK RO SI
DOCDB simple family (publication)
WO 02094794 A1 20021128; WO 02094794 A8 20040422; AR 035974 A1 20040728; AT E420866 T1 20090115; AU 2002305994 B2 20080626; BG 108333 A 20041230; BR 0209678 A 20040914; CA 2446326 A1 20021128; CA 2446326 C 20101207; CN 1269805 C 20060816; CN 1527820 A 20040908; CO 5540309 A2 20050729; CY 1108913 T1 20140702; CZ 20033092 A3 20040818; DE 60230869 D1 20090305; DK 1395567 T3 20090406; EE 05243 B1 20091215; EE 200300545 A 20040216; EP 1395567 A1 20040310; EP 1395567 B1 20090114; EP 2042495 A1 20090401; ES 2319876 T3 20090514; HK 1061237 A1 20040910; HU P0401086 A2 20040830; HU P0401086 A3 20110728; IL 158631 A0 20040512; IL 158631 A 20101230; IS 2625 B 20100515; IS 7032 A 20031113; JP 2005508293 A 20050331; JP 2010132670 A 20100617; JP 4549024 B2 20100922; JP 5028500 B2 20120919; KR 100885100 B1 20090220; KR 100915263 B1 20090903; KR 20040000471 A 20040103; KR 20080106586 A 20081208; MX PA03010445 A 20040309; MY 140070 A 20091130; NO 20035120 D0 20031117; NO 326632 B1 20090126; NZ 529401 A 20050930; NZ 539828 A 20070126; PL 367142 A1 20050221; PT 1395567 E 20090326; RU 2003131964 A 20050510; RU 2297412 C2 20070420; SI 1395567 T1 20090430; SK 13982003 A3 20040406; SK 287555 B6 20110104; US 2004147526 A1 20040729; US 2007270435 A1 20071122; US 2011039858 A1 20110217; US 7229994 B2 20070612; US 7915413 B2 20110329; US 8022074 B2 20110920
DOCDB simple family (application)
SE 0200956 W 20020516; AR P020101817 A 20020516; AT 02733712 T 20020516; AU 2002305994 A 20020516; BG 10833303 A 20031107; BR 0209678 A 20020516; CA 2446326 A 20020516; CN 02814169 A 20020516; CO 03100169 A 20031112; CY 091100308 T 20090319; CZ 20033092 A 20020516; DE 60230869 T 20020516; DK 02733712 T 20020516; EE P200300545 A 20020516; EP 02733712 A 20020516; EP 08171062 A 20020516; ES 02733712 T 20020516; HK 04104288 A 20040614; HU P0401086 A 20020516; IL 15863102 A 20020516; IL 15863103 A 20031027; IS 7032 A 20031113; JP 2002591467 A 20020516; JP 2010002450 A 20100108; KR 20037014950 A 20031117; KR 20087026556 A 20020516; MX PA03010445 A 20020516; MY PI20021785 A 20020516; NO 20035120 A 20031117; NZ 52940102 A 20020516; NZ 53982802 A 20020516; PL 36714202 A 20020516; PT 02733712 T 20020516; RU 2003131964 A 20020516; SI 200230797 T 20020516; SK 13982003 A 20020516; US 47764203 A 20031113; US 74382407 A 20070503; US 91116710 A 20101025