EP 1397342 A1 20040317 - PROCESS FOR PREPARING SERTRALINE INTERMEDIATES
Title (en)
PROCESS FOR PREPARING SERTRALINE INTERMEDIATES
Title (de)
VERFAHREN ZUR HERSTELLUNG VON SERTRALINZWISCHENPRODUKTEN
Title (fr)
PROCEDE DE PREPARATION D'INTERMEDIAIRES DE SERTRALINE
Publication
Application
Priority
- FI 0200466 W 20020530
- FI 20011146 A 20010531
- US 29426601 P 20010531
Abstract (en)
[origin: WO02096860A1] A pharmaceutical intermediate, N-[4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]methanamine, which can be used in the production of sertraline hydrochloride, is conveniently prepared by reacting 4-(3,4-dichlorophenyl)-3,4-dihydro-1-(2H)-naphthalenone with monomethylamine in a solvent which is an amide solvent with a structure of general formula (IV), wherein R1, R3 are indepen dently hydrogen or C1-6 alkyl, which can be substituted, and R2 is hydrogen.
IPC 1-7
C07C 249/02; C07C 251/20; C07C 209/52; C07C 211/42; C07C 209/26; C07C 209/40; A61K 31/135
IPC 8 full level
C07C 209/88 (2006.01); C07C 211/42 (2006.01); C07C 249/02 (2006.01); C07C 251/20 (2006.01)
CPC (source: EP)
C07C 209/88 (2013.01); C07C 211/42 (2013.01); C07C 249/02 (2013.01); C07C 2602/10 (2017.04)
Citation (search report)
See references of WO 02096860A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 02096860 A1 20021205; CA 2448300 A1 20021205; EP 1397342 A1 20040317
DOCDB simple family (application)
FI 0200466 W 20020530; CA 2448300 A 20020530; EP 02727626 A 20020530