EP 1399441 B1 20060705 - N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS
Title (en)
N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS
Title (de)
N-AROYL-(CYCLISCHES AMIN)-DERIVATE ALS OREXINREZEPTOR ANTAGONISTEN
Title (fr)
DERIVES D'AMINE CYCLIQUES N-AROYLE UTILISES COMME ANTAGONISTES DU RECEPTEUR DE L'OREXINE
Publication
Application
Priority
- EP 0207009 W 20020625
- GB 0115863 A 20010628
- GB 0130342 A 20011219
Abstract (en)
[origin: WO03002561A1] This invention relates to N-aroyl cyclic amine derivatives of formula (I), wherein X represents a bond, oxygen , NR<3> or a group (CH2), wherein n represents 1, 2 or 3; Y represents CH2, CO, CH(OH), or CH2CH(OH); Het is an optionally substituted bicyclic heteroaryl group containing up to 4 heteroatoms selected from N, O and S; Ar<2> represents an optionally substituted phenyl or a 5- or 6-membered heterocyclyl group containing up to 3 heteroatoms selected from N, O and S and their use as pharmaceuticals, specifically as orexin receptor antagonists.
IPC 8 full level
C07D 417/14 (2006.01); A61K 31/4184 (2006.01); C07D 491/048 (2006.01); A61K 31/426 (2006.01); A61K 31/445 (2006.01); A61K 31/453 (2006.01); A61K 31/454 (2006.01); A61K 31/4545 (2006.01); A61K 31/4709 (2006.01); A61K 31/496 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61P 1/04 (2006.01); A61P 1/08 (2006.01); A61P 1/14 (2006.01); A61P 3/04 (2006.01); A61P 3/10 (2006.01); A61P 5/02 (2006.01); A61P 5/10 (2006.01); A61P 5/38 (2006.01); A61P 7/00 (2006.01); A61P 9/02 (2006.01); A61P 9/04 (2006.01); A61P 9/12 (2006.01); A61P 11/06 (2006.01); A61P 13/08 (2006.01); A61P 13/10 (2006.01); A61P 13/12 (2006.01); A61P 15/00 (2006.01); A61P 19/10 (2006.01); A61P 25/00 (2006.01); A61P 25/02 (2006.01); A61P 25/04 (2006.01); A61P 25/06 (2006.01); A61P 25/08 (2006.01); A61P 25/14 (2006.01); A61P 25/16 (2006.01); A61P 25/20 (2006.01); A61P 25/22 (2006.01); A61P 25/24 (2006.01); A61P 25/28 (2006.01); A61P 35/00 (2006.01); A61P 37/08 (2006.01); C07D 401/06 (2006.01); C07D 401/14 (2006.01); C07D 403/14 (2006.01); C07D 405/06 (2006.01); C07D 405/14 (2006.01); C07D 407/06 (2006.01); C07D 407/14 (2006.01); C07D 409/14 (2006.01); C07D 411/14 (2006.01); C07D 413/14 (2006.01); C07D 417/04 (2006.01); C07D 471/04 (2006.01); C07D 491/04 (2006.01)
CPC (source: EP KR US)
A61P 1/04 (2018.01 - EP); A61P 1/08 (2018.01 - EP); A61P 1/14 (2018.01 - EP); A61P 3/00 (2018.01 - EP); A61P 3/04 (2018.01 - EP); A61P 3/10 (2018.01 - EP); A61P 5/02 (2018.01 - EP); A61P 5/10 (2018.01 - EP); A61P 5/38 (2018.01 - EP); A61P 7/00 (2018.01 - EP); A61P 9/02 (2018.01 - EP); A61P 9/04 (2018.01 - EP); A61P 9/12 (2018.01 - EP); A61P 11/06 (2018.01 - EP); A61P 13/08 (2018.01 - EP); A61P 13/10 (2018.01 - EP); A61P 13/12 (2018.01 - EP); A61P 15/00 (2018.01 - EP); A61P 19/10 (2018.01 - EP); A61P 25/00 (2018.01 - EP); A61P 25/02 (2018.01 - EP); A61P 25/04 (2018.01 - EP); A61P 25/06 (2018.01 - EP); A61P 25/08 (2018.01 - EP); A61P 25/14 (2018.01 - EP); A61P 25/16 (2018.01 - EP); A61P 25/20 (2018.01 - EP); A61P 25/22 (2018.01 - EP); A61P 25/24 (2018.01 - EP); A61P 25/28 (2018.01 - EP); A61P 35/00 (2018.01 - EP); A61P 37/08 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07D 401/06 (2013.01 - EP US); C07D 401/14 (2013.01 - EP US); C07D 403/14 (2013.01 - EP US); C07D 405/06 (2013.01 - EP US); C07D 405/14 (2013.01 - EP US); C07D 409/14 (2013.01 - EP US); C07D 413/14 (2013.01 - EP US); C07D 417/04 (2013.01 - EP US); C07D 417/14 (2013.01 - EP KR US); C07D 471/04 (2013.01 - EP US); C07D 491/04 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 03002561 A1 20030109; AR 036115 A1 20040811; AT E332300 T1 20060715; BR 0210609 A 20040720; CA 2451464 A1 20030109; CN 1549816 A 20041124; CO 5540306 A2 20050729; CZ 20033437 A3 20040915; DE 60212968 D1 20060817; DE 60212968 T2 20070201; EP 1399441 A1 20040324; EP 1399441 B1 20060705; EP 1705179 A1 20060927; ES 2266549 T3 20070301; HU P0400326 A2 20040928; IL 159041 A0 20040512; JP 2005501027 A 20050113; JP 4399256 B2 20100113; KR 20040029326 A 20040406; MX PA03011706 A 20040319; NO 20035739 D0 20031219; NO 20035739 L 20040224; PL 367677 A1 20050307; US 2004180887 A1 20040916; US 2008318944 A1 20081225; US 2009012083 A1 20090108; US 2009012122 A1 20090108; US 2009036442 A1 20090205; US 7470710 B2 20081230; US 7893090 B2 20110222; US 7897618 B2 20110301; US 7928124 B2 20110419; US 7928125 B2 20110419
DOCDB simple family (application)
EP 0207009 W 20020625; AR P020102413 A 20020626; AT 02754750 T 20020625; BR 0210609 A 20020625; CA 2451464 A 20020625; CN 02812878 A 20020625; CO 03110870 A 20031219; CZ 20033437 A 20020625; DE 60212968 T 20020625; EP 02754750 A 20020625; EP 06013820 A 20020625; ES 02754750 T 20020625; HU P0400326 A 20020625; IL 15904102 A 20020625; JP 2003508942 A 20020625; KR 20037016986 A 20031226; MX PA03011706 A 20020625; NO 20035739 A 20031219; PL 36767702 A 20020625; US 48113304 A 20040426; US 92637507 A 20071029; US 92639807 A 20071029; US 92640907 A 20071029; US 92807207 A 20071030