Global Patent Index - EP 1401456 A4

EP 1401456 A4 20050420 - METHOD FRON DETERMINING THE EFFICACY OF REVERSE CHOLESTEROL TRANSPORT ENHANCING AGENTS

Title (en)

METHOD FRON DETERMINING THE EFFICACY OF REVERSE CHOLESTEROL TRANSPORT ENHANCING AGENTS

Title (de)

VERFAHREN ZUR BESTIMMUNG DES WIRKUNGSGRADES VON VERBESSERUNGSMITTELN DES CHOLESTERINRÜCKWÄRTSTRANSPORTS

Title (fr)

PROCEDE DE DETERMINATION DE L'EFFICACITE DES AGENTS AMELIORANT LE TRANSPORT INVERSE DU CHOLESTEROL

Publication

EP 1401456 A4 20050420 (EN)

Application

EP 02725010 A 20020219

Priority

  • US 0205722 W 20020219
  • US 27035601 P 20010221

Abstract (en)

[origin: WO02067958A1] This invention provides a method for screening and/or determining the efficacy of known or potential reverse cholesterol transport-enhancing compounds in mammals that avoids the need for measuring cellular protein or mRNA levels and instead employs measurements of CD14 levels in blood.

IPC 1-7

A61K 35/60; G01N 33/92; G01N 33/50

IPC 8 full level

G01N 33/68 (2006.01); A61K 31/44 (2006.01); A61K 35/60 (2006.01); A61K 38/17 (2006.01); A61K 38/44 (2006.01); C12N 15/09 (2006.01); G01N 33/50 (2006.01); G01N 33/92 (2006.01)

CPC (source: EP)

A61K 31/44 (2013.01); A61K 38/00 (2013.01); G01N 2333/70596 (2013.01); G01N 2500/00 (2013.01)

Citation (search report)

  • [A] US 6120994 A 20000919 - TAM SHUI-PANG [CA]
  • [A] SUGIYAMA T ET AL: "Soluble CD14 mediates efflux of phospholipids from cells.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 15 JAN 2001, vol. 166, no. 2, 15 January 2001 (2001-01-15), pages 826 - 831, XP002317739, ISSN: 0022-1767
  • [DA] WURFEL MARK M ET AL: "Soluble CD14 acts as a shuttle in the neutralization of lipopolysaccharide (LPS) by LPS-binding protein and reconstituted high density lipoprotein", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 181, no. 5, 1995, pages 1743 - 1754, XP002317741, ISSN: 0022-1007 & DATABASE WPI Section Ch Week 200048, Derwent World Patents Index; Class B04, AN 1999-229918, XP002317740
  • See references of WO 02067958A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

WO 02067958 A1 20020906; CA 2438899 A1 20020906; EP 1401456 A1 20040331; EP 1401456 A4 20050420; JP 2004527737 A 20040909

DOCDB simple family (application)

US 0205722 W 20020219; CA 2438899 A 20020219; EP 02725010 A 20020219; JP 2002567324 A 20020219