EP 1404356 B1 20110406 - METHOD FOR DESIGNING CD10-ACTIVATED PRODRUG COMPOUNDS
Title (en)
METHOD FOR DESIGNING CD10-ACTIVATED PRODRUG COMPOUNDS
Title (de)
METHODE FÜR DIE AUSARBEITUNG VON CD10-AKTIVIERTEN PRODRUG-VERBINDUNGEN
Title (fr)
MÉTHODE POUR CONCEVOIR DES PROMÉDICAMENTS ACTIVÉS PAR CD10
Publication
Application
Priority
- US 0221135 W 20020611
- US 29759601 P 20010611
Abstract (en)
[origin: US7771962B2] The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the CD10 enzyme. Methods of treatment using the prodrug and methods of designing the prodrug are also disclosed.
IPC 8 full level
A61K 47/48 (2006.01); A61K 31/704 (2006.01); A61K 45/00 (2006.01); A61K 49/00 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); A61P 35/04 (2006.01); A61P 43/00 (2006.01); C07K 5/06 (2006.01); C07K 5/083 (2006.01); C12Q 1/37 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP US)
A61K 47/65 (2017.08 - EP US); A61P 35/00 (2018.01 - EP); A61P 35/02 (2018.01 - EP); A61P 35/04 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C12Q 1/37 (2013.01 - EP US); G01N 33/57492 (2013.01 - EP US); G01N 2333/70596 (2013.01 - EP US); G01N 2500/00 (2013.01 - EP US)
Citation (examination)
- WO 0168145 A2 20010920 - DU PONT PHARM CO [US]
- MARI B. ET AL: "High levels of functional endopeptidase 24.11 (CD10) activity on human thymocytes: Preferential expression on immature subsets", IMMUNOLOGY 1994 GB, vol. 82, no. 3, 1994, pages 433 - 438, ISSN: 0019-2805
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 02100353 A2 20021219; WO 02100353 A3 20030522; AT E504315 T1 20110415; AU 2002316539 B2 20080501; AU 2002316539 C1 20081030; CA 2450316 A1 20021219; DE 60239679 D1 20110519; EP 1404356 A2 20040407; EP 1404356 A4 20050406; EP 1404356 B1 20110406; ES 2364452 T3 20110902; JP 2004537527 A 20041216; JP 4541693 B2 20100908; US 2004087497 A1 20040506; US 2005267016 A1 20051201; US 2009136980 A1 20090528; US 6897034 B2 20050524; US 7304032 B2 20071204; US 7771962 B2 20100810
DOCDB simple family (application)
US 0221135 W 20020611; AT 02746852 T 20020611; AU 2002316539 A 20020611; CA 2450316 A 20020611; DE 60239679 T 20020611; EP 02746852 A 20020611; ES 02746852 T 20020611; JP 2003503179 A 20020611; US 16762702 A 20020611; US 2234104 A 20041222; US 98609607 A 20071120