EP 1404645 A2 20040407 - METHOD FOR PRODUCING OPTICALLY ACTIVE CYANOHYDRINS AND THEIR CORRESPONDING ACIDS
Title (en)
METHOD FOR PRODUCING OPTICALLY ACTIVE CYANOHYDRINS AND THEIR CORRESPONDING ACIDS
Title (de)
VERFAHREN ZUR HERSTELLUNG VON OPTISCH AKTIVEN ZYANHYDRINEN
Title (fr)
PROCEDE POUR PRODUIRE DES CYANHYDRINES OPTIQUEMENT ACTIVES ET LEURS ACIDES CORRESPONDANTS
Publication
Application
Priority
- DE 10131810 A 20010630
- EP 0206681 W 20020618
Abstract (en)
[origin: WO03005010A2] The invention relates to a method for producing optically active cyanohydrins and the corresponding alpha -hydroxycarboxylic acids, starting from an aldehyde, hydrogen cyanide and an optically active vanadyl-salen catalyst, whereby the reaction mixture is reacted at a temperature of between 0 and 60 DEG C. Between 0.8 and 10 equivalents of hydrogen cyanide and between 0.0001 and 0.05 equivalents of vanadyl-salen catalyst in relation to the aldehyde, (concentration of between 0.5 and 4 mol/litre solvent), are preferably used. After said reaction the optically active cyanohydrin or after an acid hydrolysis the corresponding optically active alpha -hydroxycarboxylic acid can be isolated with a surplus of enantiomers. The vanadium catalyst used in the invention contains a salen ligand, whereby the ratio salen ligand: vanadium (IV) in the catalyst ranges between 1.4:1 and 10:1.
IPC 1-7
IPC 8 full level
C07B 53/00 (2006.01); C07B 61/00 (2006.01); C07C 51/08 (2006.01); C07C 253/00 (2006.01); C07C 255/36 (2006.01)
CPC (source: EP US)
C07C 51/08 (2013.01 - EP US)
Citation (search report)
See references of WO 03005010A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 03005010 A2 20030116; WO 03005010 A3 20030925; DE 10131810 A1 20030227; EP 1404645 A2 20040407; JP 2004533490 A 20041104; US 2004171862 A1 20040902
DOCDB simple family (application)
EP 0206681 W 20020618; DE 10131810 A 20010630; EP 02753068 A 20020618; JP 2003510935 A 20020618; US 48224603 A 20031222