EP 1406668 A1 20040414 - COMPOSITE ONCOLYTIC HERPES VIRUS VECTORS
Title (en)
COMPOSITE ONCOLYTIC HERPES VIRUS VECTORS
Title (de)
ZUSAMMENGESETZTE ONKOLYTISCHE HERPESVIRUSVEKTOREN
Title (fr)
VECTEURS DU VIRUS DE L'HERPES ONCOLYTIQUE COMPOSITE
Publication
Application
Priority
- IL 0200345 W 20020502
- US 28771701 P 20010502
Abstract (en)
[origin: WO02087625A1] A highly efficient and safe HSV derived composite oncolytic vector is provided for the treatment of solid tumors in an individual. The vector comprises two main components being a defective viral genome with multiple reiterations of amplicon type repeat units each carrying inducible toxic genes with cell destructive capabilities and, as a second component, an HSV mutant helper virus which is incapable of replication in non-dividing cells. The vector may be used for the treatment of various kinds of solid tumors including brain malignancies as well as lung, pancreatic, kidney, colon, stomach and other types of cancers. The provided vector is also suitable for administration to an individual in combination with an additional treatment.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 39/245 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); C12N 15/869 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); C12N 15/86 (2013.01); A61K 38/00 (2013.01); A61K 48/00 (2013.01); C12N 2710/16643 (2013.01)
Citation (search report)
See references of WO 02087625A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 02087625 A1 20021107; EP 1406668 A1 20040414; JP 2004529158 A 20040924
DOCDB simple family (application)
IL 0200345 W 20020502; EP 02766686 A 20020502; JP 2002584967 A 20020502