EP 1407770 B1 20130605 - TGF-BETA SUPERFAMILY PRODUCTION/SECRETION PROMOTER
Title (en)
TGF-BETA SUPERFAMILY PRODUCTION/SECRETION PROMOTER
Title (de)
TGF-BETA SUPERFAMILIEN-PRODUKTION/SEKRETIONS-PROMOTER
Title (fr)
PROMOTEUR DE PRODUCTION/SECRETION DE LA SUPERFAMILLE DES TGF-BETA
Publication
Application
Priority
- JP 0206350 W 20020625
- JP 2001193728 A 20010626
Abstract (en)
[origin: EP1407770A1] Transforming growth factor beta (TGF-beta ) superfamily production secretion promoter comprises a 5 membered heterocycle derivative (I). TGF-beta superfamily production secretion promoter comprises a 5 membered heterocycle derivative of formula (I) or its salts or prodrugs. [Image] R 1halo or optionally substituted heterocyclyl, hydroxy, thiol or amino; A : optionally esterified or amidated carboxyl or optionally substituted acyl, heterocyclyl or hydroxy; B' : optionally substituted aromatic group; X : O, S or optionally substituted imino, and Y : divalent hydrocarbyl or heterocyclyl. ACTIVITY : Neuroprotective; Uropathic; Auditory; Osteopathic; Antidiabetic; Antiarthritic; Antirheumatic; Endocrine; Nephrotropic; Analgesic; Dermatological. MECHANISM OF ACTION : TGF-beta agonist. In a diabetic neuropathy model in SD rats, administration of 4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-[3-(2-methylphenoxy)propyl]oxazole (Ia) at 10 mg/kg/day orally for 4 months increased growth/differentiation factor-15 production to 135% of a control.
IPC 8 full level
A61K 31/422 (2006.01); A61K 45/00 (2006.01); A61P 13/10 (2006.01); A61P 19/08 (2006.01); A61P 25/02 (2006.01); A61P 27/16 (2006.01); A61P 43/00 (2006.01); C07D 413/04 (2006.01)
CPC (source: EP US)
A61K 31/422 (2013.01 - EP US); A61P 13/10 (2017.12 - EP); A61P 19/08 (2017.12 - EP); A61P 25/02 (2017.12 - EP); A61P 27/16 (2017.12 - EP); A61P 43/00 (2017.12 - EP)
Citation (examination)
WO 9717087 A1 19970515 - GENENTECH INC [US]
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
EP 1407770 A1 20040414; EP 1407770 A4 20070822; EP 1407770 B1 20130605; CA 2452114 A1 20030103; CA 2452114 C 20101116; US 2004142988 A1 20040722; US 7498352 B2 20090303; WO 03000257 A1 20030103
DOCDB simple family (application)
EP 02741288 A 20020625; CA 2452114 A 20020625; JP 0206350 W 20020625; US 48084903 A 20031216