EP 1408934 A2 20040421 - PHARMACEUTICAL COMPOSITION FOR PROPHYLAXIS AND TREATMENT OF CALCIUM METABOLISM DISORDERS COMPRISING CLODRONATE IN COMBINATION WITH GLYCERYL PALMITOSTEARATE
Title (en)
PHARMACEUTICAL COMPOSITION FOR PROPHYLAXIS AND TREATMENT OF CALCIUM METABOLISM DISORDERS COMPRISING CLODRONATE IN COMBINATION WITH GLYCERYL PALMITOSTEARATE
Title (de)
PHARMAZEUTISCHE ZUSAMMENSETZUNG ZUR PROPHYLAXE UND BEHANDLUNG VON CALCIUM METABOLISMUS STÖRUNGEN ENTHALTEND CLODRONAT IN KOMBINATION MIT GLYCERYL PALMITOSTEARAT
Title (fr)
COMPOSITION PHARMACEUTIQUE DE PROPHYLAXIE ET DE TRAITEMENT DE TROUBLES DU METABOLISME CALCIQUE comprenant du clodronate en combinaison avec le glycérylpalmitostéarate
Publication
Application
Priority
- RO 0200017 W 20020702
- RO 200100780 A 20010704
Abstract (en)
[origin: WO03004008A2] The object of the present invention is a pharmaceutical composition for oral use, in the form of hard gelatin capsules, which contains an excipient from the triglyceride class, for example atomized glyceryl palmitostearate, with double role, of lubricant and binder. The composition is used for the treatment and prophylaxis of calcium metabolism disorders, such as bone resorbtion, hypercalcemia and osteoporosis and contains as active ingredient a derivate of bisphosphonic acid, for example disodium clodronate. The active ingredient disodium clodronate tetrahydrate, granulated by fluidized bed method, is released from the preparation in a proportion of at least 75 % during the first 5 minutes and at least 95 % in 30 minutes.
IPC 1-7
IPC 8 full level
A61K 9/48 (2006.01); A61K 31/663 (2006.01); A61P 19/10 (2006.01); A61K 9/16 (2006.01)
CPC (source: EP)
A61K 9/4858 (2013.01); A61K 31/663 (2013.01); A61P 19/10 (2017.12); A61K 9/1617 (2013.01)
Citation (search report)
See references of WO 03004008A2
Citation (examination)
- EP 0275468 A1 19880727 - BOEHRINGER MANNHEIM GMBH [DE]
- GENNARO A R: "Remington: THe Science and Practice of Pharmacy", 1995, MACK PUBLISHING COMPANY, EASTON, PENNSYLVANIA (US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
DOCDB simple family (publication)
WO 03004008 A2 20030116; WO 03004008 A3 20030501; AU 2002326251 A1 20030121; EP 1408934 A2 20040421; RO 121891 B1 20080730
DOCDB simple family (application)
RO 0200017 W 20020702; AU 2002326251 A 20020702; EP 02760933 A 20020702; RO 200100780 A 20010704