Global Patent Index - EP 1408946 A4

EP 1408946 A4 20040609 - HISTONE DEACETYLASE INHIBITORS

Title (en)

HISTONE DEACETYLASE INHIBITORS

Title (de)

HISTONDEACETYLASEINHIBITOREN

Title (fr)

INHIBITEURS DE L'HISTONE DEACETYLASE

Publication

EP 1408946 A4 20040609 (EN)

Application

EP 02719311 A 20020325

Priority

  • US 0208836 W 20020325
  • US 81294001 A 20010327
  • US 81294401 A 20010327
  • US 81294501 A 20010327
  • US 2594701 A 20011226

Abstract (en)

[origin: WO02076941A2] Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, such as, for example, a hydroxamic acid group or a carboxylic acid group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene expression, including expression of genes related to tumor suppression. Accordingly, inhibition of histone deacetylase can provide an alternate route for treating cancer, hematological disorders, e.g., hemoglobinopathies, and genetic related metabolic disorders, e.g., cystic fibrosis and adrenoleukodystrophy.

IPC 1-7

A61K 31/19; C07C 261/00; C07C 69/76; C07C 269/00; C07C 259/04

IPC 8 full level

A61K 31/16 (2006.01); C07C 57/42 (2006.01); C07C 57/60 (2006.01); C07C 259/06 (2006.01); C07D 307/54 (2006.01)

CPC (source: EP)

A61K 31/16 (2013.01); C07C 57/42 (2013.01); C07C 57/60 (2013.01); C07C 259/06 (2013.01); C07D 307/54 (2013.01)

Citation (search report)

  • [X] WO 0020370 A1 20000413 - ALLERGAN SALES INC [US]
  • [X] WO 9801423 A1 19980115 - SMITHKLINE BEECHAM SPA [IT], et al
  • [X] EP 0405788 A2 19910102 - SHIONOGI & CO [JP]
  • [X] US 3886278 A 19750527 - GALLO DUANE GORDON
  • [X] RICHON V M ET AL: "A CLASS OF HYBRID POLAR INDUCERS OF TRANSFORMED CELL DIFFERENTIATION INHIBITS HISTONE DEACETYLASES", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 95, no. 6, 17 March 1998 (1998-03-17), pages 3003 - 3007, XP001120542, ISSN: 0027-8424
  • [X] PATENT ABSTRACTS OF JAPAN vol. 009, no. 184 (C - 294) 30 July 1985 (1985-07-30)
  • [Y] SCHMIDT K ET AL: "INHIBITORS OF HISTONE DEACETYLASE SUPPRESS THE GROWTH OF MCF-7 BREAST CANCER CELLS", ARCHIV DER PHARMAZIE, VCH VERLAGSGESELLSCHAFT MBH, WEINHEIM, DE, vol. 332, no. 10, 1999, pages 353 - 357, XP000985303, ISSN: 0365-6233
  • [Y] MANFRED JUNG ET AL: "Amide Analogues of Trichostatin A as Inhibitors of Histone Deacetylase and Inducers of Terminal Cell Differentiation", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 42, no. 22, 4 November 1999 (1999-11-04), pages 4669 - 4679, XP002144226, ISSN: 0022-2623
  • See references of WO 02076941A2

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

WO 02076941 A2 20021003; WO 02076941 A3 20040212; AU 2002250401 A1 20021008; CA 2442366 A1 20021003; CA 2442366 C 20120925; EP 1408946 A2 20040421; EP 1408946 A4 20040609

DOCDB simple family (application)

US 0208836 W 20020325; AU 2002250401 A 20020325; CA 2442366 A 20020325; EP 02719311 A 20020325