EP 1409731 A2 20040421 - METHODS OF MODULATING PHARMACOKINETICS OF OLIGONUCLEOTIDES
Title (en)
METHODS OF MODULATING PHARMACOKINETICS OF OLIGONUCLEOTIDES
Title (de)
VERFAHREN ZUR MODULATION DER PHARMAKOKINETIK VON OLIGONUKLEOTIDEN
Title (fr)
PROCEDES DE MODULATION DE LA PHARMACOCINETIQUE DES OLIGONUCLEOTIDES
Publication
Application
Priority
- US 0220940 W 20020701
- US 30268301 P 20010703
- US 5874002 A 20020128
Abstract (en)
[origin: WO03004603A2] 2'-<i>O</i>-(2-Methylthioethyl), has been incorporated into oligonucleotides and evaluated for antisense properties in comparison with the known 2'-<i>O</i>-(2-methoxyethyl)2'-<i>O</i>-MOE modification. The 2'-<i>O</i>-MOE modified oligonucleotides exhibit improved binding to human serum albumin compared with the 2'-<i>O</i>-MOE modified oligonucleotides and maintain high binding affinity to target RNA.
IPC 1-7
IPC 8 full level
C07H 19/06 (2006.01); C12N 15/113 (2010.01)
CPC (source: EP)
C07H 19/06 (2013.01); C12N 15/113 (2013.01); C12N 2310/321 (2013.01)
Citation (search report)
See references of WO 03004603A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
DOCDB simple family (publication)
WO 03004603 A2 20030116; WO 03004603 A3 20031204; CA 2452310 A1 20030116; EP 1409731 A2 20040421
DOCDB simple family (application)
US 0220940 W 20020701; CA 2452310 A 20020701; EP 02742381 A 20020701