EP 1412382 A2 20040428 - INTERFERON GAMMA POLYPEPTIDE VARIANTS
Title (en)
INTERFERON GAMMA POLYPEPTIDE VARIANTS
Title (de)
GAMMA-INTERFERON-POLYPEPTIDVARIANTEN
Title (fr)
VARIANTES POLYPEPTIDIQUES A INTERFERON GAMMA
Publication
Application
Priority
- DK 0200226 W 20020404
- DK PA200100579 A 20010406
- DK PA200100714 A 20010507
- DK PA200200198 A 20020211
Abstract (en)
[origin: WO02081507A2] The present invention relates to novel interferon gamma polypeptide variants having interferon gamma (IFNG) activity, methods for their preparation, pharmaceutical compositions comprising the polypeptide variants and their use in the treatment of diseases, in particular for the treatment of interstitial pulmonary diseases, such as idiopathic pulmonary fibrosis. These novel polypeptide variants all comprise the substitution S99T as compared to the amino acid sequence of huIFNG or fragments thereof. By performing this mutation the naturally occurring N-glycosylation site present at position 97 is significantly beter utilized. Preferably, the variants comprise further modifications, e.g. in order to increase the AUC of such variatns when administered subcutaneously.
IPC 1-7
IPC 8 full level
A61K 38/21 (2006.01); C12N 15/09 (2006.01); A61K 47/34 (2006.01); A61K 47/48 (2006.01); A61P 11/00 (2006.01); C07K 14/57 (2006.01); C12N 5/10 (2006.01); C12P 21/02 (2006.01)
CPC (source: EP KR)
A61P 11/00 (2018.01 - EP); A61P 31/12 (2018.01 - EP); A61P 35/00 (2018.01 - EP); C07K 14/57 (2013.01 - EP KR)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 02081507 A2 20021017; WO 02081507 A3 20040212; BG 108256 A 20041230; BR 0208596 A 20040309; CA 2443277 A1 20021017; CN 1257186 C 20060524; CN 1537117 A 20041013; EP 1412382 A2 20040428; HK 1069834 A1 20050603; HU P0303645 A2 20040128; HU P0303645 A3 20051228; IL 157896 A0 20040328; JP 2005518183 A 20050623; KR 20030094336 A 20031211; MX PA03009082 A 20041122; NO 20034432 D0 20031003; NO 20034432 L 20031029; NZ 528651 A 20060630; PL 366705 A1 20050207
DOCDB simple family (application)
DK 0200226 W 20020404; BG 10825603 A 20031010; BR 0208596 A 20020404; CA 2443277 A 20020404; CN 02807891 A 20020404; EP 02722021 A 20020404; HK 05102256 A 20050315; HU P0303645 A 20020404; IL 15789602 A 20020404; JP 2002579493 A 20020404; KR 20037013263 A 20031006; MX PA03009082 A 20020404; NO 20034432 A 20031003; NZ 52865102 A 20020404; PL 36670502 A 20020404