EP 1412390 A2 20040428 - AGENTS THAT ACTIVATE OR INHIBIT TOLL-LIKE RECEPTOR 9
Title (en)
AGENTS THAT ACTIVATE OR INHIBIT TOLL-LIKE RECEPTOR 9
Title (de)
MITTEL, DIE TLR9 AKTIVIEREN ODER HEMMEN
Title (fr)
AGENTS POUVANT ACTIVER OU INHIBER LE RECEPTEUR 9 DE TYPE TOLL
Publication
Application
Priority
- US 0223645 W 20020725
- US 30806801 P 20010726
Abstract (en)
[origin: WO03035695A2] The present invention includes molecules that bind to a peptidic segment on TLR9 and mimic the effects of the CpG motif. The CpG mimicking agents include, but are not limited to, antibodies, small-molecule compounds, peptides, peptide mimetics, and nucleic acids, including compositions comprising molecules that bind to a peptidic segment on TLR9 and mimic the effects of the CpG motif suitable for administering to a patient in need of treatment, optionally in combination with, for example, an excipient, diluant, or carrier. In addition, the present invention includes those molecules which bind to the TLR9's CXXC motifs at 255Cys-Arg-Arg 258Cys as CRRC or at 265Cys-Met-GIu 268Cys as CMEC. The present invention includes methods for modulating the immune response by inducing a Th1-type response comprising administering molecules that bind to TLR9 and mimic CpG function. These molecules also shift the host cellular response away from a Th2-type response toward the Th1-type response. Thus, administering the molecules of the present invention that bind to TLR9 may avoid the risk of Th2-mediated, immunization-induced anaphylaxis, making this method useful in immunotherapy and asthma treatment. The molecules of the present invention may be administered in combination with a particular allergen.
IPC 1-7
IPC 8 full level
C07K 16/28 (2006.01)
CPC (source: EP)
C07K 16/28 (2013.01); A61K 2039/505 (2013.01); A61K 2039/55516 (2013.01); A61K 2039/55561 (2013.01)
Citation (search report)
See references of WO 03035695A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
DOCDB simple family (publication)
WO 03035695 A2 20030501; WO 03035695 A3 20031113; AU 2002360243 A1 20030506; CN 1642982 A 20050720; EP 1412390 A2 20040428
DOCDB simple family (application)
US 0223645 W 20020725; AU 2002360243 A 20020725; CN 02818821 A 20020725; EP 02795487 A 20020725