EP 1412512 A4 20040428 - DETECTION OF RAS MUTATIONS

Title (en)

DETECTION OF RAS MUTATIONS

Title (de)

NACHWEIS VON RAS-MUTATIONEN

Title (fr)

DETECTION DE MUTATIONS DE RAS

Publication

EP 1412512 A4 20040428 (EN)

Application

EP 01977871 A 20011002

Priority

US 0142422 W 20011002
US 23741600 P 20001002

Abstract (en)

[origin: WO0229005A2] Mutations in K-ras, N-ras, and H-ras were determined using target specific primers and probes in REMS-PCR methods, nested PCR methods employing a restriction endonuclease, and REMS-PCR methods using molecular beacons.

IPC 1-7

C12P 19/34

IPC 8 full level

C12N 15/09 (2006.01); C12Q 1/44 (2006.01); C12Q 1/48 (2006.01); C12Q 1/68 (2006.01); C12Q 1/683 (2018.01); C12Q 1/6858 (2018.01); C12Q 1/6886 (2018.01)

CPC (source: EP)

C12Q 1/683 (2013.01); C12Q 1/6858 (2013.01); C12Q 1/6886 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/16 (2013.01)

Citation (search report)

[DXY] EP 0953635 A1 19991103 - ORTHO CLINICAL DIAGNOSTICS INC [US]
[DY] EP 0871767 A1 19981021 - JOHNSON & JOHNSON RES PTY LTD [AU]
[PX] WO 0149877 A1 20010712 - JOHNSON & JOHNSON RES PTY LTD [AU], et al
[DX] WARD ROBYN ET AL: "Restriction endonuclease-mediated selective polymerase chain reaction: A novel assay for the detection of K-ras mutations in clinical samples", AMERICAN JOURNAL OF PATHOLOGY, vol. 153, no. 2, August 1998 (1998-08-01), pages 373 - 379, XP002270454, ISSN: 0002-9440
[DX] FUERY CAROLINE J ET AL: "Detection of rare mutant alleles by restriction endonuclease-mediated selective-PCR: Assay design and optimization", CLINICAL CHEMISTRY, vol. 46, no. 5, May 2000 (2000-05-01), pages 620 - 624, XP002270455, ISSN: 0009-9147
[DX] ROBERTS N J ET AL: "Rapid, sensitive detection of mutant alleles in codon 12 of K-ras by REMS-PCR", BIOTECHNIQUES, vol. 27, no. 3, September 1999 (1999-09-01), pages 418;420;422, XP001179444, ISSN: 0736-6205
[DA] SOKOL D L ET AL: "Real time detection of DNA.RNA hybridization in living cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 95, no. 20, September 1998 (1998-09-01), pages 11538 - 11543, XP002123471, ISSN: 0027-8424
See references of WO 0229005A2

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

WO 0229005 A2 20020411; WO 0229005 A3 20040226; AU 9695501 A 20020415; CA 2424584 A1 20020411; EP 1412512 A2 20040428; EP 1412512 A4 20040428; JP 2004518412 A 20040624

DOCDB simple family (application)

US 0142422 W 20011002; AU 9695501 A 20011002; CA 2424584 A 20011002; EP 01977871 A 20011002; JP 2002532576 A 20011002