EP 1414490 A1 20040506 - IMMUNOMODULATORY OLIGONUCLEOTIDE FORMULATIONS AND METHODS FOR USE THEREOF
Title (en)
IMMUNOMODULATORY OLIGONUCLEOTIDE FORMULATIONS AND METHODS FOR USE THEREOF
Title (de)
IMMUNMODULATORISCHE ZUSAMMENSETZUNGEN UND VERFAHREN ZUR IHRE ANWENDUNG
Title (fr)
PREPARATIONS D'OLIGONUCLEOTIDES IMMUNOMODULATEURS ET LEURS PROCEDES D'UTILISATION
Publication
Application
Priority
- US 0125364 W 20010813
- US 92742201 A 20010810
- US 92788401 A 20010810
Abstract (en)
[origin: WO03015816A1] The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMP/MC) complexes. The IMP/MC complexes may be covalently or non-covalently bound, and feature a heptameric oligonucleotide, comprising at least one 5'-CG-3' sequence, bound to a microcarrier or nanocarrier.
IPC 1-7
IPC 8 full level
A61K 9/16 (2006.01); A61K 39/12 (2006.01); A61K 39/35 (2006.01); A61K 39/39 (2006.01); A61P 31/12 (2006.01); A61P 37/08 (2006.01); C12N 15/11 (2006.01); C12N 15/117 (2010.01); A61K 9/00 (2006.01)
CPC (source: EP)
A61K 9/1647 (2013.01); A61K 39/39 (2013.01); A61P 31/12 (2017.12); A61P 37/08 (2017.12); C12N 15/117 (2013.01); A61K 9/1617 (2013.01); A61K 9/167 (2013.01); A61K 2039/55555 (2013.01); A61K 2039/55561 (2013.01); C12N 2310/17 (2013.01); C12N 2310/315 (2013.01); C12N 2320/32 (2013.01); Y02A 50/30 (2017.12)
Citation (search report)
See references of WO 03015816A1
Citation (examination)
- MANZEL L. ET AL: "LACK OF IMMUNE STIMULATION BY IMMOBILIZED CPG-OLIGODEOXYNUCLEOTIDE", ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT, vol. 9, no. 5, October 1999 (1999-10-01), MARY ANN LIEBERT, INC., NEW YORK, US, pages 459 - 464, XP000946491
- FEARON K. ET AL: "A minimal human immunomodulatory CpG motif that potently induces IFN-gamma and IFN-alpha production", EUR. J. IMMUNOL., vol. 33, 2003, pages 2114 - 2122
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 03015816 A1 20030227; AU 2001281267 B2 20080515; CA 2456201 A1 20030227; EP 1414490 A1 20040506; JP 2005510462 A 20050421
DOCDB simple family (application)
US 0125364 W 20010813; AU 2001281267 A 20010813; CA 2456201 A 20010813; EP 01959743 A 20010813; JP 2003520774 A 20010813