EP 1414500 A4 20050112 - AKT AND REGULATION OF RA SYNOVIAL FIBROBLAST APOPTOSIS
Title (en)
AKT AND REGULATION OF RA SYNOVIAL FIBROBLAST APOPTOSIS
Title (de)
AKT UND REGULIERUNG DER SYNOVIALFIBROBLASTEN-APOPTOSIS BEI RA
Title (fr)
AKT ET REGULATION DE L'APOPTOSE DES FIBROBLASTES SYNOVIAUX DE POLYARTHRITE RHUMATOIDE (RA)
Publication
Application
Priority
- US 0211820 W 20020416
- US 28396601 P 20010416
Abstract (en)
[origin: WO02083075A2] The administration of an Akt inhibitor in a suitable carrier to a rheumatoid arthritis synovial fibroblast affords a process for inducing rheumatoid arthritis synovial fibroblast apoptosis. The Akt inhibitor is administered either as an active molecule or as a gene sequence expressible within rheumatoid arthritis synovial fibroblast cells. The gene sequence can be encompassed within a gene vector such as an adenovirus. A process for assaying rheumatoid arthritis drug candidates for apoptosis affect includes exposing a culture of rheumatoid arthritis synovial fibroblast cells to a drug candidate and monitoring apoptosis in the culture in the presence of the drug candidate. Apoptosis in the culture is compared to apoptosis induced in a duplicate culture in the presence of a known Akt inhibitor.
IPC 1-7
IPC 8 full level
A61K 31/366 (2006.01); A61K 31/4439 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61K 31/585 (2006.01); A61K 31/635 (2006.01); A61P 19/02 (2006.01); C12N 15/12 (2006.01); A61K 48/00 (2006.01)
CPC (source: EP)
A61K 31/366 (2013.01); A61K 31/4439 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 31/585 (2013.01); A61K 31/635 (2013.01); A61P 19/02 (2017.12); A61K 48/00 (2013.01)
Citation (search report)
- No further relevant documents disclosed
- See references of WO 02083075A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 02083075 A2 20021024; WO 02083075 A3 20040304; CA 2444840 A1 20021024; EP 1414500 A2 20040506; EP 1414500 A4 20050112
DOCDB simple family (application)
US 0211820 W 20020416; CA 2444840 A 20020416; EP 02731374 A 20020416