EP 1414805 A1 20040506 - INDAZOLE OR INDOLE DERIVATIVES, THEIR USE IN HUMAN MEDICINE AND MORE PARTICULARLY IN CANCEROLOGY
Title (en)
INDAZOLE OR INDOLE DERIVATIVES, THEIR USE IN HUMAN MEDICINE AND MORE PARTICULARLY IN CANCEROLOGY
Title (de)
INDAZOL- ODER INDOLDERIVATE, DEREN VERWENDUNG IN DER HUMANMEDIZIN UND INSBESONDERE IN DER ONKOLOGIE
Title (fr)
DERIVES DES INDAZOLES OU DES INDOLES, LEUR UTILISATION EN MEDECINE HUMAINE ET PLUS PARTICULIEREMENT EN CANCEROLOGIE
Publication
Application
Priority
- FR 0202638 W 20020724
- FR 0110118 A 20010727
Abstract (en)
[origin: FR2827861A1] Aryl-substituted (iso)indole and indazole derivatives (A) are new. Aryl-substituted (iso)indole and indazole derivatives (A) of formulae (I) and (II) are new Ar = phenyl, optionally substituted by one or more of halo, alkyl, alkoxy, thioalkyl, (di)alkylamino (optionally where two alkyl form a 3-6 membered ring that may contain an additional O, S or N) or an aromatic 5-6 membered heterocycle, optionally substituted as for phenyl, containing 1 or 2 O, S or N; X, Y = N or CH; Z = H, sulfonyl or acyl group; R1 = H, alkyl, 3-6C cycloalkyl or Ar; R2 = cyano, COORa1, CONHRa2, CONH(Ra2'), CON(Ra3)ORa3, CORa4, C(Ra4)=NRb, NHCORa4, NHRa4, phenyl, a 5-6 membered aromatic heterocycle containing 1-3 O, S or N, carboxy, amino (optionally substituted by 1 or 2 alkyl) or cycloalkylamino; Ra1 = Me, Et or isopropyl; Ra2 = cyclopropyl; N(Ra') = aziridinyl or azetidinyl, optionally substituted by alkyl or Ar; Ra3 = Me, Et or cyclopropyl; Ra4 = cycloalkyl, optionally substituted by alkyl or Ar; Rb = hydroxy, alkoxy (optionally containing carboxy or amino, itself optionally substituted by 1 or 2 alkyl which may together form a ring optionally containing another O, S or N), (CH2)nAr, 1-2C alkyl or cycloalkyl; n = 0 or 1. Provided that when: (1) X and Y are not both CH; (2) Z is H, R2 is cyano, COORa1, CONHRa2, CONH(Ra2'), CON(Ra3)ORa3, CORa4, C(Ra4)=NRb, NHCORa4, NHRa4, phenyl or a 5-6 membered aromatic heterocycle containing 1-3 O, S or N; and (3) Z is sulfonyl or acyl, R2 is carboxy, amino (optionally substituted by 1 or 2 alkyl) or cycloalkylamino.
IPC 1-7
C07D 231/56; C07D 413/04; C07D 209/44; C07D 209/36; A61K 31/416; A61K 31/4035; A61K 31/404; A61P 35/00
IPC 8 full level
A61K 31/416 (2006.01); A61K 31/4178 (2006.01); A61K 31/422 (2006.01); A61K 31/4245 (2006.01); A61K 31/427 (2006.01); A61K 31/433 (2006.01); A61K 31/4439 (2006.01); A61P 9/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 209/36 (2006.01); C07D 209/44 (2006.01); C07D 231/56 (2006.01); C07D 401/04 (2006.01); C07D 403/04 (2006.01); C07D 403/06 (2006.01); C07D 409/04 (2006.01); C07D 413/04 (2006.01); C07D 417/04 (2006.01)
CPC (source: EP US)
A61P 9/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 209/36 (2013.01 - EP US); C07D 209/44 (2013.01 - EP US); C07D 231/56 (2013.01 - EP US); C07D 413/04 (2013.01 - EP US)
Citation (search report)
See references of WO 03011833A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
DOCDB simple family (publication)
FR 2827861 A1 20030131; FR 2827861 B1 20040402; AR 036348 A1 20040901; EP 1414805 A1 20040506; JP 2005503376 A 20050203; US 2004162276 A1 20040819; US 7119115 B2 20061010; WO 03011833 A1 20030213
DOCDB simple family (application)
FR 0110118 A 20010727; AR P020102840 A 20020726; EP 02791508 A 20020724; FR 0202638 W 20020724; JP 2003517025 A 20020724; US 76198204 A 20040121